Synthesis and Anticancer Activity of Glucosylated Podophyllotoxin Derivatives Linked via 4β-Triazole Rings

Synthesis and Anticancer Activity of Glucosylated Podophyllotoxin Derivatives Linked via 4β-Triazole Rings

A series of 4β-triazole-linked glucose podophyllotoxin conjugates have been designed and synthesized by employing a click chemistry approach. All the compounds were evaluated for their anticancer activity against a panel of five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480) using M...

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Bibliographic Details
Main Authors: Cheng-Ting Zi, Feng-Qing Xu, Gen-Tao Li, Yan Li, Zhong-Tao Ding, Jun Zhou, Zi-Hua Jiang, Jiang-Miao Hu
Format: Article
Language:English
Published: MDPI AG 2013-11-01
Series:Molecules
Subjects:
podophyllotoxin
4β-triazole ring
click chemistry
anticancer activity
Online Access:http://www.mdpi.com/1420-3049/18/11/13992

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http://www.mdpi.com/1420-3049/18/11/13992

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