Dynamic Regulation of a Ribosome Rescue Pathway in Erythroid Cells and Platelets

Protein synthesis continues in platelets and maturing reticulocytes, although these blood cells lack nuclei and do not make new mRNA or ribosomes. Here, we analyze translation in primary human cells from anucleate lineages by ribosome profiling and uncover a dramatic accumulation of post-termination...

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Bibliographic Details
Main Authors: Eric W. Mills, Jamie Wangen, Rachel Green, Nicholas T. Ingolia
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716311974