Administration of Bacterial Lipopolysaccharide during Early Postnatal Ontogenesis Induces Transient Impairment of Long-Term Synaptic Plasticity Associated with Behavioral Abnormalities in Young Rats

Administration of Bacterial Lipopolysaccharide during Early Postnatal Ontogenesis Induces Transient Impairment of Long-Term Synaptic Plasticity Associated with Behavioral Abnormalities in Young Rats

Infectious diseases in early postnatal ontogenesis often result in cognitive impairments, particularly learning and memory. The essential foundation of learning and memory is long-term synaptic plasticity, which depends on N-methyl-D-aspartate (NMDA) receptors. In the present study, bacterial infect...

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Bibliographic Details
Main Authors: Tatyana Y. Postnikova, Alexandra V. Griflyuk, Julia L. Ergina, Olga E. Zubareva, Aleksey V. Zaitsev
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Pharmaceuticals
Subjects:
bacterial lipopolysaccharide
long-term potentiation
hippocampus
open field test
early life
Online Access:https://www.mdpi.com/1424-8247/13/3/48

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