Protein Translocation into the Intermembrane Space and Matrix of Mitochondria: Mechanisms and Driving Forces

Mitochondria contain two aqueous subcompartments, the matrix and the intermembrane space (IMS). The matrix is enclosed by both the inner and outer mitochondrial membranes, whilst the IMS is sandwiched between the two. Proteins of the matrix are synthesized in the cytosol as preproteins, which contai...

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Bibliographic Details
Main Authors: Sandra Backes, Johannes M. Herrmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Molecular Biosciences
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fmolb.2017.00083/full