Therapeutic benefits of music-based synchronous finger tapping in Parkinson’s disease—an fNIRS study protocol for randomized controlled trial in Dalian, China
Abstract Background Music therapy improves neuronal activity and connectivity of healthy persons and patients with clinical symptoms of neurological diseases like Parkinson’s disease, Alzheimer’s disease, and major depression. Despite the plethora of publications that have reported the positive effe...
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doaj-ba7878b120fa4b5992b4089f4d3adcec2020-11-25T02:46:18ZengBMCTrials1745-62152020-10-0121111410.1186/s13063-020-04770-9Therapeutic benefits of music-based synchronous finger tapping in Parkinson’s disease—an fNIRS study protocol for randomized controlled trial in Dalian, ChinaLanlan Pu0Nauman Khalid Qureshi1Joanne Ly2Bingwei Zhang3Fengyu Cong4William C. Tang5Zhanhua Liang6Department of Neurology, the First Affiliated Hospital of Dalian Medical UniversitySchool of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of TechnologyDepartment of Biomedical Engineering, University of CaliforniaDepartment of Neurology, the First Affiliated Hospital of Dalian Medical UniversitySchool of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of TechnologyDepartment of Biomedical Engineering, University of CaliforniaDepartment of Neurology, the First Affiliated Hospital of Dalian Medical UniversityAbstract Background Music therapy improves neuronal activity and connectivity of healthy persons and patients with clinical symptoms of neurological diseases like Parkinson’s disease, Alzheimer’s disease, and major depression. Despite the plethora of publications that have reported the positive effects of music interventions, little is known about how music improves neuronal activity and connectivity in afflicted patients. Methods For patients suffering from Parkinson’s disease (PD), we propose a daily 25-min music-based synchronous finger tapping (SFT) intervention for 8 weeks. Eligible participants with PD are split into two groups: an intervention group and a control arm. In addition, a third cohort of healthy controls will be recruited. Assessment of finger tapping performances, the Unified Parkinson’s Disease Rating Scale (UPDRS), an n-back test, the Montreal Cognitive Assessment (MoCA), as well as oxygenated hemoglobin (HbO2), deoxygenated hemoglobin (HbR), and total hemoglobin activation collected by functional near-infrared spectroscopy (fNIRS) are measured at baseline, week 4 (during), week 8 (post), and week 12 (retention) of the study. Data collected from the two PD groups are compared to baseline performances from healthy controls. Discussion This exploratory prospective trial study investigates the cortical neuronal activity and therapeutic effects associated with an auditory external cue used to induce automatic and implicit synchronous finger tapping in patients diagnosed with PD. The extent to which the intervention is effective may be dependent on the severity of the disease. The study’s findings are used to inform larger clinical studies for optimization and further exploration of the therapeutic effects of movement-based music therapy on neural activity in neurological diseases. Trial registration ClinicalTrials.gov NCT04212897 . Registered on December 30, 2019. The participant recruitment and study protocol have received ethical approval from the First Affiliated Hospital of Dalian Medical University. The hospital Protocol Record number is PJ-KY-2019-123. The protocol was named “fNIRS Studies of Music Intervention of Parkinson’s Disease.” The current protocol is version 1.1, revised on September 1, 2020.http://link.springer.com/article/10.1186/s13063-020-04770-9Music therapyParkinson’s diseasefNIRSRandomized controlled trialsExplicit and implicit timingMotor-control |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lanlan Pu Nauman Khalid Qureshi Joanne Ly Bingwei Zhang Fengyu Cong William C. Tang Zhanhua Liang |
spellingShingle |
Lanlan Pu Nauman Khalid Qureshi Joanne Ly Bingwei Zhang Fengyu Cong William C. Tang Zhanhua Liang Therapeutic benefits of music-based synchronous finger tapping in Parkinson’s disease—an fNIRS study protocol for randomized controlled trial in Dalian, China Trials Music therapy Parkinson’s disease fNIRS Randomized controlled trials Explicit and implicit timing Motor-control |
author_facet |
Lanlan Pu Nauman Khalid Qureshi Joanne Ly Bingwei Zhang Fengyu Cong William C. Tang Zhanhua Liang |
author_sort |
Lanlan Pu |
title |
Therapeutic benefits of music-based synchronous finger tapping in Parkinson’s disease—an fNIRS study protocol for randomized controlled trial in Dalian, China |
title_short |
Therapeutic benefits of music-based synchronous finger tapping in Parkinson’s disease—an fNIRS study protocol for randomized controlled trial in Dalian, China |
title_full |
Therapeutic benefits of music-based synchronous finger tapping in Parkinson’s disease—an fNIRS study protocol for randomized controlled trial in Dalian, China |
title_fullStr |
Therapeutic benefits of music-based synchronous finger tapping in Parkinson’s disease—an fNIRS study protocol for randomized controlled trial in Dalian, China |
title_full_unstemmed |
Therapeutic benefits of music-based synchronous finger tapping in Parkinson’s disease—an fNIRS study protocol for randomized controlled trial in Dalian, China |
title_sort |
therapeutic benefits of music-based synchronous finger tapping in parkinson’s disease—an fnirs study protocol for randomized controlled trial in dalian, china |
publisher |
BMC |
series |
Trials |
issn |
1745-6215 |
publishDate |
2020-10-01 |
description |
Abstract Background Music therapy improves neuronal activity and connectivity of healthy persons and patients with clinical symptoms of neurological diseases like Parkinson’s disease, Alzheimer’s disease, and major depression. Despite the plethora of publications that have reported the positive effects of music interventions, little is known about how music improves neuronal activity and connectivity in afflicted patients. Methods For patients suffering from Parkinson’s disease (PD), we propose a daily 25-min music-based synchronous finger tapping (SFT) intervention for 8 weeks. Eligible participants with PD are split into two groups: an intervention group and a control arm. In addition, a third cohort of healthy controls will be recruited. Assessment of finger tapping performances, the Unified Parkinson’s Disease Rating Scale (UPDRS), an n-back test, the Montreal Cognitive Assessment (MoCA), as well as oxygenated hemoglobin (HbO2), deoxygenated hemoglobin (HbR), and total hemoglobin activation collected by functional near-infrared spectroscopy (fNIRS) are measured at baseline, week 4 (during), week 8 (post), and week 12 (retention) of the study. Data collected from the two PD groups are compared to baseline performances from healthy controls. Discussion This exploratory prospective trial study investigates the cortical neuronal activity and therapeutic effects associated with an auditory external cue used to induce automatic and implicit synchronous finger tapping in patients diagnosed with PD. The extent to which the intervention is effective may be dependent on the severity of the disease. The study’s findings are used to inform larger clinical studies for optimization and further exploration of the therapeutic effects of movement-based music therapy on neural activity in neurological diseases. Trial registration ClinicalTrials.gov NCT04212897 . Registered on December 30, 2019. The participant recruitment and study protocol have received ethical approval from the First Affiliated Hospital of Dalian Medical University. The hospital Protocol Record number is PJ-KY-2019-123. The protocol was named “fNIRS Studies of Music Intervention of Parkinson’s Disease.” The current protocol is version 1.1, revised on September 1, 2020. |
topic |
Music therapy Parkinson’s disease fNIRS Randomized controlled trials Explicit and implicit timing Motor-control |
url |
http://link.springer.com/article/10.1186/s13063-020-04770-9 |
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