A cell-based in vitro assay for testing of immunological integrity of Tetanus toxoid vaccine antigen

Abstract Vaccines containing inactivated toxins confer protection by eliciting a neutralizing antibody response against bacterial toxins such as tetanus and diphtheria. At present, release of tetanus toxoid (TT) and diphtheria toxoid (DT)-containing vaccines relies on in vivo experiments showing the...

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Bibliographic Details
Main Authors: Olga Ticha, Dido Klemm, Lukas Moos, Isabelle Bekeredjian-Ding
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-021-00344-1