Attainment of target rifampicin concentrations in cerebrospinal fluid during treatment of tuberculous meningitis

Objective: There is considerable uncertainty regarding the optimal use of rifampicin for the treatment of tuberculous (TB) meningitis. A pharmacokinetic modeling and simulation study of rifampicin concentrations in cerebrospinal fluid (CSF) during TB meningitis treatment was performed in this study....

Full description

Bibliographic Details
Main Authors: Alyssa Mezochow, Kiran T. Thakur, Isaac Zentner, Selvakumar Subbian, Leonid Kagan, Christopher Vinnard
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:International Journal of Infectious Diseases
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971219301973