Electrophilically Activated Nitroalkanes in Double Annulation of [1,2,4]Triazolo[4,3-<i>a</i>]quinolines and 1,3,4-Oxadiazole Rings

Nitroalkanes activated with polyphosphoric acid could serve as efficient electrophiles in reactions with amines and hydrazines, enabling various cascade transformations toward heterocyclic systems. This strategy was developed for an innovative synthetic protocol employing simultaneous or sequential...

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Main Authors:	Alexander V. Aksenov, Nikita K. Kirilov, Nicolai A. Aksenov, Dmitrii A. Aksenov, Elena A. Sorokina, Carolyn Lower, Michael Rubin
Format:	Article
Language:	English
Published:	MDPI AG 2021-09-01
Series:	Molecules
Subjects:	nitroalkanes heterocycles annulation cascade transformations
Online Access:	https://www.mdpi.com/1420-3049/26/18/5692

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spelling	doaj-bbba14949c464ad5ad7c575ed57fcd402021-09-26T00:47:13ZengMDPI AGMolecules1420-30492021-09-01265692569210.3390/molecules26185692Electrophilically Activated Nitroalkanes in Double Annulation of [1,2,4]Triazolo[4,3-<i>a</i>]quinolines and 1,3,4-Oxadiazole RingsAlexander V. Aksenov0Nikita K. Kirilov1Nicolai A. Aksenov2Dmitrii A. Aksenov3Elena A. Sorokina4Carolyn Lower5Michael Rubin6Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, RussiaDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, RussiaDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, RussiaDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, RussiaOrganic Chemistry Department, Peoples’ Friendship, University of Russia (RUDN University), 6, Miklukho-Maklaya St., 117198 Moscow, RussiaDepartment of Chemistry, University of Kansas, 1567 Irving Hill Road, Lawrence, KS 66045, USADepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, RussiaNitroalkanes activated with polyphosphoric acid could serve as efficient electrophiles in reactions with amines and hydrazines, enabling various cascade transformations toward heterocyclic systems. This strategy was developed for an innovative synthetic protocol employing simultaneous or sequential annulation of two different heterocyclic cores, affording [1,2,4]triazolo[4,3-<i>a</i>]quinolines with 1,3,4-oxadiazole substituents.https://www.mdpi.com/1420-3049/26/18/5692nitroalkanesheterocyclesannulationcascade transformations
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Alexander V. Aksenov Nikita K. Kirilov Nicolai A. Aksenov Dmitrii A. Aksenov Elena A. Sorokina Carolyn Lower Michael Rubin
spellingShingle	Alexander V. Aksenov Nikita K. Kirilov Nicolai A. Aksenov Dmitrii A. Aksenov Elena A. Sorokina Carolyn Lower Michael Rubin Electrophilically Activated Nitroalkanes in Double Annulation of [1,2,4]Triazolo[4,3-<i>a</i>]quinolines and 1,3,4-Oxadiazole Rings Molecules nitroalkanes heterocycles annulation cascade transformations
author_facet	Alexander V. Aksenov Nikita K. Kirilov Nicolai A. Aksenov Dmitrii A. Aksenov Elena A. Sorokina Carolyn Lower Michael Rubin
author_sort	Alexander V. Aksenov
title	Electrophilically Activated Nitroalkanes in Double Annulation of [1,2,4]Triazolo[4,3-<i>a</i>]quinolines and 1,3,4-Oxadiazole Rings
title_short	Electrophilically Activated Nitroalkanes in Double Annulation of [1,2,4]Triazolo[4,3-<i>a</i>]quinolines and 1,3,4-Oxadiazole Rings
title_full	Electrophilically Activated Nitroalkanes in Double Annulation of [1,2,4]Triazolo[4,3-<i>a</i>]quinolines and 1,3,4-Oxadiazole Rings
title_fullStr	Electrophilically Activated Nitroalkanes in Double Annulation of [1,2,4]Triazolo[4,3-<i>a</i>]quinolines and 1,3,4-Oxadiazole Rings
title_full_unstemmed	Electrophilically Activated Nitroalkanes in Double Annulation of [1,2,4]Triazolo[4,3-<i>a</i>]quinolines and 1,3,4-Oxadiazole Rings
title_sort	electrophilically activated nitroalkanes in double annulation of [1,2,4]triazolo[4,3-<i>a</i>]quinolines and 1,3,4-oxadiazole rings
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2021-09-01
description	Nitroalkanes activated with polyphosphoric acid could serve as efficient electrophiles in reactions with amines and hydrazines, enabling various cascade transformations toward heterocyclic systems. This strategy was developed for an innovative synthetic protocol employing simultaneous or sequential annulation of two different heterocyclic cores, affording [1,2,4]triazolo[4,3-<i>a</i>]quinolines with 1,3,4-oxadiazole substituents.
topic	nitroalkanes heterocycles annulation cascade transformations
url	https://www.mdpi.com/1420-3049/26/18/5692
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Electrophilically Activated Nitroalkanes in Double Annulation of [1,2,4]Triazolo[4,3-<i>a</i>]quinolines and 1,3,4-Oxadiazole Rings

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