The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer
Colorectal cancer (CRC) is now the second-leading cause of cancer deaths in the USA. Colorectal cancer progression and metastasis depends on the orchestration of the aberrant signaling pathways that control tumor cell proliferation, survival and migration/invasion. Epidemiological, clinical, and ani...
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2011-10-01
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Online Access: | http://www.mdpi.com/2072-6694/3/4/3894/ |
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doaj-bbd4ad05d7f74b3d8ec074bd69faf7ab2020-11-24T23:35:32ZengMDPI AGCancers2072-66942011-10-01343894390810.3390/cancers3043894The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal CancerDingzhi WangDianren XiaRaymond N. DuBoisColorectal cancer (CRC) is now the second-leading cause of cancer deaths in the USA. Colorectal cancer progression and metastasis depends on the orchestration of the aberrant signaling pathways that control tumor cell proliferation, survival and migration/invasion. Epidemiological, clinical, and animal studies have demonstrated that prostaglandin-endoperoxide synthase 2 (PTGS2) and epithelial growth factor (EGF) signaling pathways play key roles in promoting colorectal cancer growth and metastasis. In this review, we highlight major advances in our understanding of the roles of PTGS2 and EGF signaling in colorectal cancer.http://www.mdpi.com/2072-6694/3/4/3894/PTGS2COX-2EGFRcolorectal cancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dingzhi Wang Dianren Xia Raymond N. DuBois |
spellingShingle |
Dingzhi Wang Dianren Xia Raymond N. DuBois The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer Cancers PTGS2 COX-2 EGFR colorectal cancer |
author_facet |
Dingzhi Wang Dianren Xia Raymond N. DuBois |
author_sort |
Dingzhi Wang |
title |
The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer |
title_short |
The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer |
title_full |
The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer |
title_fullStr |
The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer |
title_full_unstemmed |
The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer |
title_sort |
crosstalk of ptgs2 and egf signaling pathways in colorectal cancer |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2011-10-01 |
description |
Colorectal cancer (CRC) is now the second-leading cause of cancer deaths in the USA. Colorectal cancer progression and metastasis depends on the orchestration of the aberrant signaling pathways that control tumor cell proliferation, survival and migration/invasion. Epidemiological, clinical, and animal studies have demonstrated that prostaglandin-endoperoxide synthase 2 (PTGS2) and epithelial growth factor (EGF) signaling pathways play key roles in promoting colorectal cancer growth and metastasis. In this review, we highlight major advances in our understanding of the roles of PTGS2 and EGF signaling in colorectal cancer. |
topic |
PTGS2 COX-2 EGFR colorectal cancer |
url |
http://www.mdpi.com/2072-6694/3/4/3894/ |
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