The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer

Colorectal cancer (CRC) is now the second-leading cause of cancer deaths in the USA. Colorectal cancer progression and metastasis depends on the orchestration of the aberrant signaling pathways that control tumor cell proliferation, survival and migration/invasion. Epidemiological, clinical, and ani...

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Main Authors: Dingzhi Wang, Dianren Xia, Raymond N. DuBois
Format: Article
Language:English
Published: MDPI AG 2011-10-01
Series:Cancers
Subjects:
Online Access:http://www.mdpi.com/2072-6694/3/4/3894/
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spelling doaj-bbd4ad05d7f74b3d8ec074bd69faf7ab2020-11-24T23:35:32ZengMDPI AGCancers2072-66942011-10-01343894390810.3390/cancers3043894The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal CancerDingzhi WangDianren XiaRaymond N. DuBoisColorectal cancer (CRC) is now the second-leading cause of cancer deaths in the USA. Colorectal cancer progression and metastasis depends on the orchestration of the aberrant signaling pathways that control tumor cell proliferation, survival and migration/invasion. Epidemiological, clinical, and animal studies have demonstrated that prostaglandin-endoperoxide synthase 2 (PTGS2) and epithelial growth factor (EGF) signaling pathways play key roles in promoting colorectal cancer growth and metastasis. In this review, we highlight major advances in our understanding of the roles of PTGS2 and EGF signaling in colorectal cancer.http://www.mdpi.com/2072-6694/3/4/3894/PTGS2COX-2EGFRcolorectal cancer
collection DOAJ
language English
format Article
sources DOAJ
author Dingzhi Wang
Dianren Xia
Raymond N. DuBois
spellingShingle Dingzhi Wang
Dianren Xia
Raymond N. DuBois
The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer
Cancers
PTGS2
COX-2
EGFR
colorectal cancer
author_facet Dingzhi Wang
Dianren Xia
Raymond N. DuBois
author_sort Dingzhi Wang
title The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer
title_short The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer
title_full The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer
title_fullStr The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer
title_full_unstemmed The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer
title_sort crosstalk of ptgs2 and egf signaling pathways in colorectal cancer
publisher MDPI AG
series Cancers
issn 2072-6694
publishDate 2011-10-01
description Colorectal cancer (CRC) is now the second-leading cause of cancer deaths in the USA. Colorectal cancer progression and metastasis depends on the orchestration of the aberrant signaling pathways that control tumor cell proliferation, survival and migration/invasion. Epidemiological, clinical, and animal studies have demonstrated that prostaglandin-endoperoxide synthase 2 (PTGS2) and epithelial growth factor (EGF) signaling pathways play key roles in promoting colorectal cancer growth and metastasis. In this review, we highlight major advances in our understanding of the roles of PTGS2 and EGF signaling in colorectal cancer.
topic PTGS2
COX-2
EGFR
colorectal cancer
url http://www.mdpi.com/2072-6694/3/4/3894/
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