Hepatic cannabinoid receptor type 1 mediates alcohol-induced regulation of bile acid enzyme genes expression via CREBH.

Hepatic cannabinoid receptor type 1 mediates alcohol-induced regulation of bile acid enzyme genes expression via CREBH.

Bile acids concentration in liver is tightly regulated to prevent cell damage. Previous studies have demonstrated that deregulation of bile acid homeostasis can lead to cholestatic liver disease. Recently, we have shown that ER-bound transcription factor Crebh is a downstream effector of hepatic Cb1...

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Main Authors: Dipanjan Chanda, Yong-Hoon Kim, Tiangang Li, Jagannath Misra, Don-Kyu Kim, Jung Ran Kim, Joseph Kwon, Won-Il Jeong, Sung-Hoon Ahn, Tae-Sik Park, Seung-Hoi Koo, John Y L Chiang, Chul-Ho Lee, Hueng-Sik Choi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3718807?pdf=render

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http://europepmc.org/articles/PMC3718807?pdf=render

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