Estimated survival time in gastric cancer patients and its associated factors

• Main Authors: Ghodratollah Roshanaei, Sanambar Sadighi, Maliheh Safari, Javad Faradmal
• Format: Article
• Language: fas
• Published: Semnan Univeristy of Medical Sciences 2012-09-01
• Series: Majallah-i ̒Ilmī-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Simnān
• Subjects: Stomach neoplasms; Neoplasm metastasis; Proportional hazards model; Survival analysis; Survival rate
• Online Access: http://koomeshjournal.ir/browse.php?a_id=1616&sid=1&slc_lang=fa

Introduction: Gastric cancer is the second most common cancer after lung cancer and the leading causeof cancer mortality. Gastric cancer of the lining of the stomach gradually affects the adjacent layers ofstomach and spreads out. With studying the characteristics of these patients and determining factors inpredicting affecting survival, it may be possible to predict or to improve their survival.Materials and Methods: In this study, 199 patients with metastatic gastric cancer were studied and theage at the time of diagnosis, type of treatment, degree of tumor differentiation, the number of sites involvedand many other factors affecting the length of survival time of patients were evaluated. For data analysis,Kaplan-Meier and Cox proportional hazards model were used.Results: 151 patients (75.9%) were male and 71 patients (35.7%) died in the end of follow-up. The meanand median survival time of patients was 24.7±3.9 and 19 months, respectively. Survival probability of one,three and five year of patients were 0.66, 0.19 and 0.06, respectively. Fitted model showed that age atdiagnosis and level of hemoglobin associated with survival in patients with metastatic gastric cancers(P<0.05).Conclusion: With early diagnosis in patients with gastric cancer, risk can be greatly reduced