Let-7b/c enhance the stability of a tissue-specific mRNA during mammalian organogenesis as part of a feedback loop involving KSRP.

Let-7b/c enhance the stability of a tissue-specific mRNA during mammalian organogenesis as part of a feedback loop involving KSRP.

Gene silencing mediated by either microRNAs (miRNAs) or Adenylate/uridylate-rich elements Mediated mRNA Degradation (AMD) is a powerful way to post-transcriptionally modulate gene expression. We and others have reported that the RNA-binding protein KSRP favors the biogenesis of select miRNAs (includ...

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Bibliographic Details
Main Authors: Emanuela Repetto, Paola Briata, Nathalie Kuziner, Brian D Harfe, Michael T McManus, Roberto Gherzi, Michael G Rosenfeld, Michele Trabucchi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3405994?pdf=render

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http://europepmc.org/articles/PMC3405994?pdf=render

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