Interaction of Di-2-pyridylketone 2-pyridine Carboxylic Acid Hydrazone and Its Copper Complex with BSA: Effect on Antitumor Activity as Revealed by Spectroscopic Studies

Interaction of Di-2-pyridylketone 2-pyridine Carboxylic Acid Hydrazone and Its Copper Complex with BSA: Effect on Antitumor Activity as Revealed by Spectroscopic Studies

The drug, di-2-pyridylketone-2-pyridine carboxylic acid hydrazone (DPPCAH) and its copper complex (DPPCAH-Cu) exhibit significant antitumor activity. However, the mechanism of their pharmacological interaction with the biological molecule bovine serum albumin (BSA) remains poorly understood. The pre...

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Bibliographic Details
Main Authors: Cuiping Li, Tengfei Huang, Yun Fu, Youxun Liu, Sufeng Zhou, Zhangyang Qi, Changzheng Li
Format: Article
Language:English
Published: MDPI AG 2016-04-01
Series:Molecules
Subjects:
di-2-pyridylketone 2-pyridine carboxylic acid hydrazone
copper complex
fluorescence
FRET
molecular docking
Online Access:http://www.mdpi.com/1420-3049/21/5/563

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http://www.mdpi.com/1420-3049/21/5/563

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