Versatile chimeric antigen receptor platform for controllable and combinatorial T cell therapy

Versatile chimeric antigen receptor platform for controllable and combinatorial T cell therapy

Chimeric antigen receptor (CAR) T cells show remarkable therapeutic effects in some hematological malignancies. However, CAR T cells can also cause life-threatening side effects. In order to minimize off-target and on-target/off-tumor reactions, improve safety, enable controllability, provide high f...

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Bibliographic Details
Main Authors: Anja Feldmann, Anja Hoffmann, Ralf Bergmann, Stefanie Koristka, Nicole Berndt, Claudia Arndt, Liliana Rodrigues Loureiro, Enrico Kittel-Boselli, Nicola Mitwasi, Alexandra Kegler, Chris Lamprecht, Karla Elizabeth González Soto, Michael Bachmann
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:OncoImmunology
Subjects:
chimeric antigen receptor (car)
t cell therapy
tumor immunotherapy
adaptor car platform
combinatorial gated targeting
Online Access:http://dx.doi.org/10.1080/2162402X.2020.1785608

Internet

http://dx.doi.org/10.1080/2162402X.2020.1785608

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