Metabolic reprogramming for producing energy and reducing power in fumarate hydratase null cells from hereditary leiomyomatosis renal cell carcinoma.

Metabolic reprogramming for producing energy and reducing power in fumarate hydratase null cells from hereditary leiomyomatosis renal cell carcinoma.

Fumarate hydratase (FH)-deficient kidney cancer undergoes metabolic remodeling, with changes in mitochondrial respiration, glucose, and glutamine metabolism. These changes represent multiple biochemical adaptations in glucose and fatty acid metabolism that supports malignant proliferation. However,...

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Bibliographic Details
Main Authors: Youfeng Yang, Andrew N Lane, Christopher J Ricketts, Carole Sourbier, Ming-Hui Wei, Brian Shuch, Lisa Pike, Min Wu, Tracey A Rouault, Laszlo G Boros, Teresa W-M Fan, W Marston Linehan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3744468?pdf=render

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http://europepmc.org/articles/PMC3744468?pdf=render

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