A single nucleotide polymorphism associated with reduced alcohol intake in the RASGRF2 gene predicts larger cortical volumes but faster longitudinal ventricular expansion in the elderly

A single nucleotide polymorphism associated with reduced alcohol intake in the RASGRF2 gene predicts larger cortical volumes but faster longitudinal ventricular expansion in the elderly

A recent genome-wide association meta-analysis showed a suggestive association between alcohol intake in humans and a common single nucleotide polymorphism (SNP) in the ras-specific guanine nucleotide releasing factor 2 (RASGFR2) gene. Here, we tested whether this variant - associated with lower alc...

Full description

Bibliographic Details
Main Authors: Florence F Roussotte, Boris A Gutman, Derrek P Hibar, Neda eJahanshad, Sarah K Madsen, Clifford R Jack, Mike W Weiner, Paul M Thompson
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Aging Neuroscience
Subjects:
aging neuroscience
Neuroimaging genetics
structural MRI
ventricular expansion
rasgrf2
brain volume
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2013.00093/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2013.00093/full

Similar Items