Richter's transformation as leptomeningeal infiltration in a chronic lymphocytic leukemia patient receiving venetoclax. Could blood‐brain barrier be a disease “sanctuary” during venetoclax treatment?

Abstract Our unique case of Richter's Transformation presenting as leptomeningial infiltration in a CLL patient receiving venetoclax raises questions on whether the drug penetrates the blood‐brain barrier and at what extend, especially in reduced doses given for drug‐drug interactions.

Bibliographic Details
Main Authors:	Maria Dimou, Aikaterini Bitsani, Maria Roumelioti, Aglaia Dimitrakopoulou, Theodore Iliakis, Vasileios Pardalis, Ioannis Grafakos, Sotiria Kalyva, Athanasios Markopoulos, Marie‐Christine Kyrtsonis, Panayiotis Panayiotidis
Format:	Article
Language:	English
Published:	Wiley 2021-04-01
Series:	Clinical Case Reports
Subjects:	blood‐brain barrier chronic lymphocytic leukemia leptomeningeal infiltration Richter's transformation venetoclax
Online Access:	https://doi.org/10.1002/ccr3.4002

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spelling	doaj-bd5d28430ca74e60a6e31c467814826e2021-05-15T18:35:45ZengWileyClinical Case Reports2050-09042021-04-01942249225310.1002/ccr3.4002Richter's transformation as leptomeningeal infiltration in a chronic lymphocytic leukemia patient receiving venetoclax. Could blood‐brain barrier be a disease “sanctuary” during venetoclax treatment?Maria Dimou0Aikaterini Bitsani1Maria Roumelioti2Aglaia Dimitrakopoulou3Theodore Iliakis4Vasileios Pardalis5Ioannis Grafakos6Sotiria Kalyva7Athanasios Markopoulos8Marie‐Christine Kyrtsonis9Panayiotis Panayiotidis101st Propedeutic Internal Medicine Clinic Hematology Department and Molecular Laboratory in Hematology National and Kapodistrian University of Athens Athens Greece1st Propedeutic Internal Medicine Clinic Hematology Department and Molecular Laboratory in Hematology National and Kapodistrian University of Athens Athens Greece1st Propedeutic Internal Medicine Clinic Hematology Department and Molecular Laboratory in Hematology National and Kapodistrian University of Athens Athens Greece1st Propedeutic Internal Medicine Clinic Hematology Department and Molecular Laboratory in Hematology National and Kapodistrian University of Athens Athens Greece1st Propedeutic Internal Medicine Clinic Hematology Department and Molecular Laboratory in Hematology National and Kapodistrian University of Athens Athens Greece1st Propedeutic Internal Medicine Clinic Hematology Department and Molecular Laboratory in Hematology National and Kapodistrian University of Athens Athens Greece1st Propedeutic Internal Medicine Clinic Hematology Department and Molecular Laboratory in Hematology National and Kapodistrian University of Athens Athens Greece1st Propedeutic Internal Medicine Clinic Hematology Department and Molecular Laboratory in Hematology National and Kapodistrian University of Athens Athens Greece1st Propedeutic Internal Medicine Clinic Hematology Department and Molecular Laboratory in Hematology National and Kapodistrian University of Athens Athens Greece1st Propedeutic Internal Medicine Clinic Hematology Department and Molecular Laboratory in Hematology National and Kapodistrian University of Athens Athens Greece1st Propedeutic Internal Medicine Clinic Hematology Department and Molecular Laboratory in Hematology National and Kapodistrian University of Athens Athens GreeceAbstract Our unique case of Richter's Transformation presenting as leptomeningial infiltration in a CLL patient receiving venetoclax raises questions on whether the drug penetrates the blood‐brain barrier and at what extend, especially in reduced doses given for drug‐drug interactions.https://doi.org/10.1002/ccr3.4002blood‐brain barrierchronic lymphocytic leukemialeptomeningeal infiltrationRichter's transformationvenetoclax
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Maria Dimou Aikaterini Bitsani Maria Roumelioti Aglaia Dimitrakopoulou Theodore Iliakis Vasileios Pardalis Ioannis Grafakos Sotiria Kalyva Athanasios Markopoulos Marie‐Christine Kyrtsonis Panayiotis Panayiotidis
spellingShingle	Maria Dimou Aikaterini Bitsani Maria Roumelioti Aglaia Dimitrakopoulou Theodore Iliakis Vasileios Pardalis Ioannis Grafakos Sotiria Kalyva Athanasios Markopoulos Marie‐Christine Kyrtsonis Panayiotis Panayiotidis Richter's transformation as leptomeningeal infiltration in a chronic lymphocytic leukemia patient receiving venetoclax. Could blood‐brain barrier be a disease “sanctuary” during venetoclax treatment? Clinical Case Reports blood‐brain barrier chronic lymphocytic leukemia leptomeningeal infiltration Richter's transformation venetoclax
author_facet	Maria Dimou Aikaterini Bitsani Maria Roumelioti Aglaia Dimitrakopoulou Theodore Iliakis Vasileios Pardalis Ioannis Grafakos Sotiria Kalyva Athanasios Markopoulos Marie‐Christine Kyrtsonis Panayiotis Panayiotidis
author_sort	Maria Dimou
title	Richter's transformation as leptomeningeal infiltration in a chronic lymphocytic leukemia patient receiving venetoclax. Could blood‐brain barrier be a disease “sanctuary” during venetoclax treatment?
title_short	Richter's transformation as leptomeningeal infiltration in a chronic lymphocytic leukemia patient receiving venetoclax. Could blood‐brain barrier be a disease “sanctuary” during venetoclax treatment?
title_full	Richter's transformation as leptomeningeal infiltration in a chronic lymphocytic leukemia patient receiving venetoclax. Could blood‐brain barrier be a disease “sanctuary” during venetoclax treatment?
title_fullStr	Richter's transformation as leptomeningeal infiltration in a chronic lymphocytic leukemia patient receiving venetoclax. Could blood‐brain barrier be a disease “sanctuary” during venetoclax treatment?
title_full_unstemmed	Richter's transformation as leptomeningeal infiltration in a chronic lymphocytic leukemia patient receiving venetoclax. Could blood‐brain barrier be a disease “sanctuary” during venetoclax treatment?
title_sort	richter's transformation as leptomeningeal infiltration in a chronic lymphocytic leukemia patient receiving venetoclax. could blood‐brain barrier be a disease “sanctuary” during venetoclax treatment?
publisher	Wiley
series	Clinical Case Reports
issn	2050-0904
publishDate	2021-04-01
description	Abstract Our unique case of Richter's Transformation presenting as leptomeningial infiltration in a CLL patient receiving venetoclax raises questions on whether the drug penetrates the blood‐brain barrier and at what extend, especially in reduced doses given for drug‐drug interactions.
topic	blood‐brain barrier chronic lymphocytic leukemia leptomeningeal infiltration Richter's transformation venetoclax
url	https://doi.org/10.1002/ccr3.4002
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Richter's transformation as leptomeningeal infiltration in a chronic lymphocytic leukemia patient receiving venetoclax. Could blood‐brain barrier be a disease “sanctuary” during venetoclax treatment?

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