Plasmodium falciparum cGMP-Dependent Protein Kinase – A Novel Chemotherapeutic Target

The primary effector of cGMP signaling in Plasmodium is the cGMP-dependent protein kinase (PKG). Work in human-infective Plasmodium falciparum and rodent-infective Plasmodium berghei has provided biological validation of P. falciparum PKG (PfPKG) as a drug target for treating and/or protecting again...

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Main Authors:	David Rotella, John Siekierka, Purnima Bhanot
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-02-01
Series:	Frontiers in Microbiology
Subjects:	Plasmodium malaria cGMP signaling second messenger kinase
Online Access:	https://www.frontiersin.org/articles/10.3389/fmicb.2020.610408/full

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spelling	doaj-bdc2d2f5c84f44a890a477d0bd24f4f22021-02-03T04:24:01ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2021-02-011110.3389/fmicb.2020.610408610408Plasmodium falciparum cGMP-Dependent Protein Kinase – A Novel Chemotherapeutic TargetDavid Rotella0John Siekierka1Purnima Bhanot2Department of Chemistry and Biochemistry, Montclair State University, Montclair, NJ, United StatesDepartment of Chemistry and Biochemistry, Montclair State University, Montclair, NJ, United StatesDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ, United StatesThe primary effector of cGMP signaling in Plasmodium is the cGMP-dependent protein kinase (PKG). Work in human-infective Plasmodium falciparum and rodent-infective Plasmodium berghei has provided biological validation of P. falciparum PKG (PfPKG) as a drug target for treating and/or protecting against malaria. PfPKG is essential in the asexual erythrocytic and sexual cycles as well as the pre-erythrocytic cycle. Medicinal chemistry efforts, both target-based and phenotype-based, have targeted PfPKG in the past few years. This review provides a brief overview of their results and challenges.https://www.frontiersin.org/articles/10.3389/fmicb.2020.610408/fullPlasmodiummalariacGMP signalingsecond messengerkinase
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	David Rotella John Siekierka Purnima Bhanot
spellingShingle	David Rotella John Siekierka Purnima Bhanot Plasmodium falciparum cGMP-Dependent Protein Kinase – A Novel Chemotherapeutic Target Frontiers in Microbiology Plasmodium malaria cGMP signaling second messenger kinase
author_facet	David Rotella John Siekierka Purnima Bhanot
author_sort	David Rotella
title	Plasmodium falciparum cGMP-Dependent Protein Kinase – A Novel Chemotherapeutic Target
title_short	Plasmodium falciparum cGMP-Dependent Protein Kinase – A Novel Chemotherapeutic Target
title_full	Plasmodium falciparum cGMP-Dependent Protein Kinase – A Novel Chemotherapeutic Target
title_fullStr	Plasmodium falciparum cGMP-Dependent Protein Kinase – A Novel Chemotherapeutic Target
title_full_unstemmed	Plasmodium falciparum cGMP-Dependent Protein Kinase – A Novel Chemotherapeutic Target
title_sort	plasmodium falciparum cgmp-dependent protein kinase – a novel chemotherapeutic target
publisher	Frontiers Media S.A.
series	Frontiers in Microbiology
issn	1664-302X
publishDate	2021-02-01
description	The primary effector of cGMP signaling in Plasmodium is the cGMP-dependent protein kinase (PKG). Work in human-infective Plasmodium falciparum and rodent-infective Plasmodium berghei has provided biological validation of P. falciparum PKG (PfPKG) as a drug target for treating and/or protecting against malaria. PfPKG is essential in the asexual erythrocytic and sexual cycles as well as the pre-erythrocytic cycle. Medicinal chemistry efforts, both target-based and phenotype-based, have targeted PfPKG in the past few years. This review provides a brief overview of their results and challenges.
topic	Plasmodium malaria cGMP signaling second messenger kinase
url	https://www.frontiersin.org/articles/10.3389/fmicb.2020.610408/full
work_keys_str_mv	AT davidrotella plasmodiumfalciparumcgmpdependentproteinkinaseanovelchemotherapeutictarget AT johnsiekierka plasmodiumfalciparumcgmpdependentproteinkinaseanovelchemotherapeutictarget AT purnimabhanot plasmodiumfalciparumcgmpdependentproteinkinaseanovelchemotherapeutictarget
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Plasmodium falciparum cGMP-Dependent Protein Kinase – A Novel Chemotherapeutic Target

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