The Evolving Landscape of PD-1/PD-L1 Pathway in Head and Neck Cancer

The Evolving Landscape of PD-1/PD-L1 Pathway in Head and Neck Cancer

Over the past 10 years, cancer immunotherapy has made significant progress in multiple cancer types and has been gradually been applied to clinical cancer care, in which the programmed cell death protein-1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway is one of the most attractive targets. C...

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Main Authors: Xin-wei Qiao, Jian Jiang, Xin Pang, Mei-chang Huang, Ya-jie Tang, Xin-hua Liang, Ya-ling Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
PD-1
PD-L1
head and neck
prognostic
immunotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01721/full
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spelling doaj-bdd23499d5ae4414889506698ede54cd2020-11-25T03:56:37ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-09-011110.3389/fimmu.2020.01721542855The Evolving Landscape of PD-1/PD-L1 Pathway in Head and Neck CancerXin-wei Qiao0Jian Jiang1Xin Pang2Mei-chang Huang3Ya-jie Tang4Xin-hua Liang5Ya-ling Tang6State Key Laboratory of Oral Diseases, Department of Oral Pathology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaDepartment of Head and Neck Surgery, Sichuan Cancer Center, School of Medicine, Sichuan Cancer Hospital & Institute, University of Electronic Science and Technology of China, Chengdu, ChinaState Key Laboratory of Oral Diseases, Department of Oral Pathology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, Department of Oral Pathology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Microbial Technology, Shandong University, Qingdao, ChinaState Key Laboratory of Oral Diseases, Department of Oral Pathology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, Department of Oral Pathology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaOver the past 10 years, cancer immunotherapy has made significant progress in multiple cancer types and has been gradually been applied to clinical cancer care, in which the programmed cell death protein-1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway is one of the most attractive targets. Compared with traditional therapies, the emerging PD-1/PD-L1 blockade immunotherapy exhibited more satisfactory curative effects and lower toxicity for patients with advanced head and neck squamous cell carcinoma (HNSCC). This review analyzes the expression characteristics and clinical significance of PD-1/PD-L1 in HNSCC, the immunosuppressive roles of tumor cell and stromal cell expressing PD-1/PD-L1 in this disease, and presents the development landscape of PD-1/PD-L1 inhibitors, which may provide new curative alternatives for recurrent or metastatic HNSCC.https://www.frontiersin.org/article/10.3389/fimmu.2020.01721/fullPD-1PD-L1head and neckprognosticimmunotherapy
collection DOAJ
language English
format Article
sources DOAJ
author Xin-wei Qiao
Jian Jiang
Xin Pang
Mei-chang Huang
Ya-jie Tang
Xin-hua Liang
Ya-ling Tang
spellingShingle Xin-wei Qiao
Jian Jiang
Xin Pang
Mei-chang Huang
Ya-jie Tang
Xin-hua Liang
Ya-ling Tang
The Evolving Landscape of PD-1/PD-L1 Pathway in Head and Neck Cancer
Frontiers in Immunology
PD-1
PD-L1
head and neck
prognostic
immunotherapy
author_facet Xin-wei Qiao
Jian Jiang
Xin Pang
Mei-chang Huang
Ya-jie Tang
Xin-hua Liang
Ya-ling Tang
author_sort Xin-wei Qiao
title The Evolving Landscape of PD-1/PD-L1 Pathway in Head and Neck Cancer
title_short The Evolving Landscape of PD-1/PD-L1 Pathway in Head and Neck Cancer
title_full The Evolving Landscape of PD-1/PD-L1 Pathway in Head and Neck Cancer
title_fullStr The Evolving Landscape of PD-1/PD-L1 Pathway in Head and Neck Cancer
title_full_unstemmed The Evolving Landscape of PD-1/PD-L1 Pathway in Head and Neck Cancer
title_sort evolving landscape of pd-1/pd-l1 pathway in head and neck cancer
publisher Frontiers Media S.A.
series Frontiers in Immunology
issn 1664-3224
publishDate 2020-09-01
description Over the past 10 years, cancer immunotherapy has made significant progress in multiple cancer types and has been gradually been applied to clinical cancer care, in which the programmed cell death protein-1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway is one of the most attractive targets. Compared with traditional therapies, the emerging PD-1/PD-L1 blockade immunotherapy exhibited more satisfactory curative effects and lower toxicity for patients with advanced head and neck squamous cell carcinoma (HNSCC). This review analyzes the expression characteristics and clinical significance of PD-1/PD-L1 in HNSCC, the immunosuppressive roles of tumor cell and stromal cell expressing PD-1/PD-L1 in this disease, and presents the development landscape of PD-1/PD-L1 inhibitors, which may provide new curative alternatives for recurrent or metastatic HNSCC.
topic PD-1
PD-L1
head and neck
prognostic
immunotherapy
url https://www.frontiersin.org/article/10.3389/fimmu.2020.01721/full
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