Statin-Induced Autoimmune Necrotizing Myopathy
Statin therapy is a widely prescribed medication class for hypercholesterolemia. In statin-induced autoimmune myopathy, genetically predisposed and at-risk patients can develop antibodies against hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the key enzyme in the production of cholesterol. As a re...
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doaj-be175a0dc583411f92fa384180cd25582021-07-03T22:03:31ZengSAGE PublishingJournal of Primary Care & Community Health2150-13272021-07-011210.1177/21501327211028714Statin-Induced Autoimmune Necrotizing MyopathySahani Jayatilaka0Kunal Desai1Swarup Rijal2Debra Zimmerman3Reading Hospital, West Reading, PA, USAReading Hospital, West Reading, PA, USAReading Hospital, West Reading, PA, USAReading Hospital, West Reading, PA, USAStatin therapy is a widely prescribed medication class for hypercholesterolemia. In statin-induced autoimmune myopathy, genetically predisposed and at-risk patients can develop antibodies against hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the key enzyme in the production of cholesterol. As a result, an autoimmune reaction causing weakness, myalgia, with possible severe rhabdomyolysis, renal failure, and myonecrosis also can occur. A 73-year-old female presented to clinic with myalgia and fatigue. She was on atorvastatin 20 mg/day for over 1 year, which she stopped 1 week prior to her initial presentation. Patient did experience rhabdomyolysis as well as a transaminitis. She underwent an autoimmune workup which was positive for HMG-CoA reductase antibodies. Patient was initially treated on a prednisone taper, starting dose 50 mg/day. Without remission of symptoms, methotrexate 15 mg/week was initiated.https://doi.org/10.1177/21501327211028714 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sahani Jayatilaka Kunal Desai Swarup Rijal Debra Zimmerman |
spellingShingle |
Sahani Jayatilaka Kunal Desai Swarup Rijal Debra Zimmerman Statin-Induced Autoimmune Necrotizing Myopathy Journal of Primary Care & Community Health |
author_facet |
Sahani Jayatilaka Kunal Desai Swarup Rijal Debra Zimmerman |
author_sort |
Sahani Jayatilaka |
title |
Statin-Induced Autoimmune Necrotizing Myopathy |
title_short |
Statin-Induced Autoimmune Necrotizing Myopathy |
title_full |
Statin-Induced Autoimmune Necrotizing Myopathy |
title_fullStr |
Statin-Induced Autoimmune Necrotizing Myopathy |
title_full_unstemmed |
Statin-Induced Autoimmune Necrotizing Myopathy |
title_sort |
statin-induced autoimmune necrotizing myopathy |
publisher |
SAGE Publishing |
series |
Journal of Primary Care & Community Health |
issn |
2150-1327 |
publishDate |
2021-07-01 |
description |
Statin therapy is a widely prescribed medication class for hypercholesterolemia. In statin-induced autoimmune myopathy, genetically predisposed and at-risk patients can develop antibodies against hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the key enzyme in the production of cholesterol. As a result, an autoimmune reaction causing weakness, myalgia, with possible severe rhabdomyolysis, renal failure, and myonecrosis also can occur. A 73-year-old female presented to clinic with myalgia and fatigue. She was on atorvastatin 20 mg/day for over 1 year, which she stopped 1 week prior to her initial presentation. Patient did experience rhabdomyolysis as well as a transaminitis. She underwent an autoimmune workup which was positive for HMG-CoA reductase antibodies. Patient was initially treated on a prednisone taper, starting dose 50 mg/day. Without remission of symptoms, methotrexate 15 mg/week was initiated. |
url |
https://doi.org/10.1177/21501327211028714 |
work_keys_str_mv |
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