Simvastatin Inhibits Activation of NADPH Oxidase/p38 MAPK Pathway and Enhances Expression of Antioxidant Protein in Parkinson Disease Models

Simvastatin Inhibits Activation of NADPH Oxidase/p38 MAPK Pathway and Enhances Expression of Antioxidant Protein in Parkinson Disease Models

Evidence suggests that oxidative stress is involved in the pathogenesis of Parkinson disease (PD). Simvastatin has been suggested to protect against oxidative stress in several diseases. However, the molecular mechanisms by which simvastatin protects against neuropathology and oxidative damage in PD...

Full description

Bibliographic Details
Main Authors: Huichun Tong, Xiuping Zhang, Xingjun Meng, Lingli Lu, Dongmei Mai, Shaogang Qu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Parkinson disease
simvastatin
NADPH oxidase
oxidative stress
anti-oxidase
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00165/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00165/full

Similar Items