Ginsenosides from Korean Red Ginseng ameliorate lung inflammatory responses: inhibition of the MAPKs/NF-κB/c-Fos pathways
Background: Korean Red Ginseng (steamed and dried white ginseng, Panax ginseng Meyer) is well known for enhancing vital energy and immune capacity and for inhibiting cancer cell growth. Some clinical studies also demonstrated a therapeutic potential of ginseng extract for treating lung inflammatory...
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doaj-bf0db0fde4dc442ebf8127eaf10d12472020-11-24T20:50:42ZengElsevierJournal of Ginseng Research1226-84532018-10-01424476484Ginsenosides from Korean Red Ginseng ameliorate lung inflammatory responses: inhibition of the MAPKs/NF-κB/c-Fos pathwaysJu Hee Lee0Dong Suk Min1Chan Woo Lee2Kwang Ho Song3Yeong Shik Kim4Hyun Pyo Kim5College of Pharmacy, Kangwon National University, Chuncheon, Republic of KoreaCollege of Pharmacy, Kangwon National University, Chuncheon, Republic of KoreaCollege of Pharmacy, Kangwon National University, Chuncheon, Republic of KoreaCollege of Pharmacy, Seoul National University, Seoul, Republic of KoreaCollege of Pharmacy, Seoul National University, Seoul, Republic of KoreaCollege of Pharmacy, Kangwon National University, Chuncheon, Republic of Korea; Corresponding author. College of Pharmacy, Kangwon National University, 1-Gangwondaehak-gil, Chuncheon 24341, Republic of Korea.Background: Korean Red Ginseng (steamed and dried white ginseng, Panax ginseng Meyer) is well known for enhancing vital energy and immune capacity and for inhibiting cancer cell growth. Some clinical studies also demonstrated a therapeutic potential of ginseng extract for treating lung inflammatory disorders. This study was conducted to establish the therapeutic potential of ginseng saponins on the lung inflammatory response. Methods: From Korean Red Ginseng, 11 ginsenosides (Rb1, Rb2, Rb3, Rc, Rd, Re, Rf, Rg1, Rg2, Rg3, and Rh2) were isolated. Their inhibitory potential and action mechanism were evaluated using a mouse model of lung inflammation, acute lung injury induced by intranasal lipopolysaccharide administration. Their anti-inflammatory activities were also examined in lung epithelial cell line (A549) and alveolar macrophage (MH-S). Results: All ginsenosides orally administered at 20 mg/kg showed 11.5–51.6% reduction of total cell numbers in bronchoalveolar lavage fluid (BALF). Among the ginsenosides, Rc, Re, Rg1, and Rh2 exhibited significant inhibitory action by reducing total cell numbers in the BALF by 34.1–51.6% (n = 5). Particularly, Re showed strong and comparable inhibitory potency with that of dexamethasone, as judged by the number of infiltrated cells and histological observations. Re treatment clearly inhibited the activation of mitogen-activated protein kinases, nuclear factor-κB, and the c-Fos component in the lung tissue (n = 3). Conclusion: Certain ginsenosides inhibit lung inflammatory responses by interrupting these signaling molecules and they are potential therapeutics for inflammatory lung diseases. Keywords: Panax ginseng, ginsenoside, lung inflammation, MAPK, NF-κBhttp://www.sciencedirect.com/science/article/pii/S1226845316302767 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ju Hee Lee Dong Suk Min Chan Woo Lee Kwang Ho Song Yeong Shik Kim Hyun Pyo Kim |
spellingShingle |
Ju Hee Lee Dong Suk Min Chan Woo Lee Kwang Ho Song Yeong Shik Kim Hyun Pyo Kim Ginsenosides from Korean Red Ginseng ameliorate lung inflammatory responses: inhibition of the MAPKs/NF-κB/c-Fos pathways Journal of Ginseng Research |
author_facet |
Ju Hee Lee Dong Suk Min Chan Woo Lee Kwang Ho Song Yeong Shik Kim Hyun Pyo Kim |
author_sort |
Ju Hee Lee |
title |
Ginsenosides from Korean Red Ginseng ameliorate lung inflammatory responses: inhibition of the MAPKs/NF-κB/c-Fos pathways |
title_short |
Ginsenosides from Korean Red Ginseng ameliorate lung inflammatory responses: inhibition of the MAPKs/NF-κB/c-Fos pathways |
title_full |
Ginsenosides from Korean Red Ginseng ameliorate lung inflammatory responses: inhibition of the MAPKs/NF-κB/c-Fos pathways |
title_fullStr |
Ginsenosides from Korean Red Ginseng ameliorate lung inflammatory responses: inhibition of the MAPKs/NF-κB/c-Fos pathways |
title_full_unstemmed |
Ginsenosides from Korean Red Ginseng ameliorate lung inflammatory responses: inhibition of the MAPKs/NF-κB/c-Fos pathways |
title_sort |
ginsenosides from korean red ginseng ameliorate lung inflammatory responses: inhibition of the mapks/nf-κb/c-fos pathways |
publisher |
Elsevier |
series |
Journal of Ginseng Research |
issn |
1226-8453 |
publishDate |
2018-10-01 |
description |
Background: Korean Red Ginseng (steamed and dried white ginseng, Panax ginseng Meyer) is well known for enhancing vital energy and immune capacity and for inhibiting cancer cell growth. Some clinical studies also demonstrated a therapeutic potential of ginseng extract for treating lung inflammatory disorders. This study was conducted to establish the therapeutic potential of ginseng saponins on the lung inflammatory response. Methods: From Korean Red Ginseng, 11 ginsenosides (Rb1, Rb2, Rb3, Rc, Rd, Re, Rf, Rg1, Rg2, Rg3, and Rh2) were isolated. Their inhibitory potential and action mechanism were evaluated using a mouse model of lung inflammation, acute lung injury induced by intranasal lipopolysaccharide administration. Their anti-inflammatory activities were also examined in lung epithelial cell line (A549) and alveolar macrophage (MH-S). Results: All ginsenosides orally administered at 20 mg/kg showed 11.5–51.6% reduction of total cell numbers in bronchoalveolar lavage fluid (BALF). Among the ginsenosides, Rc, Re, Rg1, and Rh2 exhibited significant inhibitory action by reducing total cell numbers in the BALF by 34.1–51.6% (n = 5). Particularly, Re showed strong and comparable inhibitory potency with that of dexamethasone, as judged by the number of infiltrated cells and histological observations. Re treatment clearly inhibited the activation of mitogen-activated protein kinases, nuclear factor-κB, and the c-Fos component in the lung tissue (n = 3). Conclusion: Certain ginsenosides inhibit lung inflammatory responses by interrupting these signaling molecules and they are potential therapeutics for inflammatory lung diseases. Keywords: Panax ginseng, ginsenoside, lung inflammation, MAPK, NF-κB |
url |
http://www.sciencedirect.com/science/article/pii/S1226845316302767 |
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