Food and Sex-Related Impacts on the Pharmacokinetics of a Single-Dose of Ginsenoside Compound K in Healthy Subjects

Food and Sex-Related Impacts on the Pharmacokinetics of a Single-Dose of Ginsenoside Compound K in Healthy Subjects

Background and Objectives: Ginsenoside compound K (CK) is a candidate drug for rheumatoid arthritis therapy. This clinical trial was designed to evaluate the effects of food and sex on the pharmacokinetics of CK and its metabolite 20(S)-protopanaxadiol (PPD).Methods: An open-label, single-center, tw...

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Bibliographic Details
Main Authors: Lulu Chen, Luping Zhou, Yaqin Wang, Guoping Yang, Jie Huang, Zhirong Tan, Yicheng Wang, Gan Zhou, Jianwei Liao, Dongsheng Ouyang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Pharmacology
Subjects:
clinical trial
food effect
sex effect
ginsenosides compound K
pharmacokinetics
ChiCTR-IPR-15005787
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00636/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00636/full

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