Variability in subpopulation formation propagates into biocatalytic variability of engineered Pseudomonas putida strains

Variability in subpopulation formation propagates into biocatalytic variability of engineered Pseudomonas putida strains

Pivotal challenges in industrial biotechnology are the identification and overcoming of cell-to-cell heterogeneity in microbial processes. While the development of subpopulations of isogenic cells in bioprocesses is well described (intra-population variability), a possible variability between geneti...

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Bibliographic Details
Main Authors: Martin eLindmeyer, Michael eJahn, Carsten eVorpahl, Susann eMüller, Andreas eSchmid, Bruno eBühler
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Microbiology
Subjects:
Flow Cytometry
Pseudomonas putida
Phenotypic heterogeneity
clonal variability
Fluorescent reporter
Plasmid copy number
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.01042/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.01042/full

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