Radiotherapy and Cytokine Storm: Risk and Mechanism
Radiotherapy (RT) shows advantages as one of the most important precise therapy strategies for cancer treatment, especially high-dose hypofractionated RT which is widely used in clinical applications due to the protection of local anatomical structure and relatively mild impairment. With the increas...
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doaj-bfa05fdf690d4bdca280a30669b0be2c2021-05-20T06:36:34ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-05-011110.3389/fonc.2021.670464670464Radiotherapy and Cytokine Storm: Risk and MechanismChen Zhang0Zhenzhen Liang1Shumei Ma2Shumei Ma3Xiaodong Liu4Xiaodong Liu5School of Public Health and Management, Wenzhou Medical University, Wenzhou, ChinaNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, ChinaSchool of Public Health and Management, Wenzhou Medical University, Wenzhou, ChinaKey Laboratory of Watershed Science and Health of Zhejiang Province, Wenzhou Medical University, Wenzhou, ChinaSchool of Public Health and Management, Wenzhou Medical University, Wenzhou, ChinaKey Laboratory of Watershed Science and Health of Zhejiang Province, Wenzhou Medical University, Wenzhou, ChinaRadiotherapy (RT) shows advantages as one of the most important precise therapy strategies for cancer treatment, especially high-dose hypofractionated RT which is widely used in clinical applications due to the protection of local anatomical structure and relatively mild impairment. With the increase of single dose, ranging from 2~20 Gy, and the decrease of fractionation, the question that if there is any uniform standard of dose limits for different therapeutic regimens attracts more and more attention, and the potential adverse effects of higher dose radiation have not been elucidated. In this study, the immunological adverse responses induced by radiation, especially the cytokine storm and the underlying mechanisms such as DAMPs release, pro-inflammatory cytokine secretion and cGAS-STING pathway activation, will be elucidated, which contributes to achieving optimal hypofractionated RT regimen, improving the killing of cancer cells and avoiding the severe side effects.https://www.frontiersin.org/articles/10.3389/fonc.2021.670464/fullradiotherapycytokine stormradiotherapy—adverse effectsimmune activationimmune suppressiondose limitation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chen Zhang Zhenzhen Liang Shumei Ma Shumei Ma Xiaodong Liu Xiaodong Liu |
spellingShingle |
Chen Zhang Zhenzhen Liang Shumei Ma Shumei Ma Xiaodong Liu Xiaodong Liu Radiotherapy and Cytokine Storm: Risk and Mechanism Frontiers in Oncology radiotherapy cytokine storm radiotherapy—adverse effects immune activation immune suppression dose limitation |
author_facet |
Chen Zhang Zhenzhen Liang Shumei Ma Shumei Ma Xiaodong Liu Xiaodong Liu |
author_sort |
Chen Zhang |
title |
Radiotherapy and Cytokine Storm: Risk and Mechanism |
title_short |
Radiotherapy and Cytokine Storm: Risk and Mechanism |
title_full |
Radiotherapy and Cytokine Storm: Risk and Mechanism |
title_fullStr |
Radiotherapy and Cytokine Storm: Risk and Mechanism |
title_full_unstemmed |
Radiotherapy and Cytokine Storm: Risk and Mechanism |
title_sort |
radiotherapy and cytokine storm: risk and mechanism |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2021-05-01 |
description |
Radiotherapy (RT) shows advantages as one of the most important precise therapy strategies for cancer treatment, especially high-dose hypofractionated RT which is widely used in clinical applications due to the protection of local anatomical structure and relatively mild impairment. With the increase of single dose, ranging from 2~20 Gy, and the decrease of fractionation, the question that if there is any uniform standard of dose limits for different therapeutic regimens attracts more and more attention, and the potential adverse effects of higher dose radiation have not been elucidated. In this study, the immunological adverse responses induced by radiation, especially the cytokine storm and the underlying mechanisms such as DAMPs release, pro-inflammatory cytokine secretion and cGAS-STING pathway activation, will be elucidated, which contributes to achieving optimal hypofractionated RT regimen, improving the killing of cancer cells and avoiding the severe side effects. |
topic |
radiotherapy cytokine storm radiotherapy—adverse effects immune activation immune suppression dose limitation |
url |
https://www.frontiersin.org/articles/10.3389/fonc.2021.670464/full |
work_keys_str_mv |
AT chenzhang radiotherapyandcytokinestormriskandmechanism AT zhenzhenliang radiotherapyandcytokinestormriskandmechanism AT shumeima radiotherapyandcytokinestormriskandmechanism AT shumeima radiotherapyandcytokinestormriskandmechanism AT xiaodongliu radiotherapyandcytokinestormriskandmechanism AT xiaodongliu radiotherapyandcytokinestormriskandmechanism |
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1721435710678892544 |