The Relationship between Serum Zinc Level and Preeclampsia: A Meta-Analysis
The association between serum zinc level and preeclampsia (PE) remains controversial. A systematic literature search was performed in PubMed, Web of Science and Embase for relevant available articles. The articles were limited to those in English from January 1990 to April 2015. Observational studie...
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doaj-bfb6147bec054daf8c0490e7fa617f342020-11-24T22:36:06ZengMDPI AGNutrients2072-66432015-09-01797806782010.3390/nu7095366nu7095366The Relationship between Serum Zinc Level and Preeclampsia: A Meta-AnalysisYue Ma0Xiaoli Shen1Dongfeng Zhang2Department of epidemiology and health statistics, Medical college, Qingdao University, No.38 Dengzhou Road, Qingdao 266021, ChinaDepartment of epidemiology and health statistics, Medical college, Qingdao University, No.38 Dengzhou Road, Qingdao 266021, ChinaDepartment of epidemiology and health statistics, Medical college, Qingdao University, No.38 Dengzhou Road, Qingdao 266021, ChinaThe association between serum zinc level and preeclampsia (PE) remains controversial. A systematic literature search was performed in PubMed, Web of Science and Embase for relevant available articles. The articles were limited to those in English from January 1990 to April 2015. Observational studies evaluating the association between serum zinc level and PE were included. The I2 was used to assess heterogeneity and the random effect model (REM) was adopted as the pooling method. The pooled standard mean difference (SMD) with 95% confidence interval (CI) was used to estimate the association between serum zinc level and PE. Seventeen observational studies were included. Compared with healthy pregnancy controls, PE patients have lower serum zinc level in 14 studies about total PE (SMD (95% CI): −0.587 (−0.963, −0.212), Z = 3.06, p for Z = 0.002; I2 = 88.4%, p for I2 < 0.0001). In subgroup analysis, a lower serum zinc level in PE patients compared with healthy pregnancy controls was observed in studies conducted in Asia, studies with zinc level measured in serum, and studies involving fasting participants. The SMD did not differ significantly between studies with healthy pregnancy controls matched by individual age (yes or no), and by individual gestational age (yes or no), respectively. Results from this meta-analysis indicate that serum zinc level in PE patients is significantly lower than that in healthy pregnancy controls. A moderate amount of zinc supplementation during pregnancy is advocated to reduce the incidence of PE.http://www.mdpi.com/2072-6643/7/9/5366zincZnpreeclampsiameta-analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yue Ma Xiaoli Shen Dongfeng Zhang |
spellingShingle |
Yue Ma Xiaoli Shen Dongfeng Zhang The Relationship between Serum Zinc Level and Preeclampsia: A Meta-Analysis Nutrients zinc Zn preeclampsia meta-analysis |
author_facet |
Yue Ma Xiaoli Shen Dongfeng Zhang |
author_sort |
Yue Ma |
title |
The Relationship between Serum Zinc Level and Preeclampsia: A Meta-Analysis |
title_short |
The Relationship between Serum Zinc Level and Preeclampsia: A Meta-Analysis |
title_full |
The Relationship between Serum Zinc Level and Preeclampsia: A Meta-Analysis |
title_fullStr |
The Relationship between Serum Zinc Level and Preeclampsia: A Meta-Analysis |
title_full_unstemmed |
The Relationship between Serum Zinc Level and Preeclampsia: A Meta-Analysis |
title_sort |
relationship between serum zinc level and preeclampsia: a meta-analysis |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2015-09-01 |
description |
The association between serum zinc level and preeclampsia (PE) remains controversial. A systematic literature search was performed in PubMed, Web of Science and Embase for relevant available articles. The articles were limited to those in English from January 1990 to April 2015. Observational studies evaluating the association between serum zinc level and PE were included. The I2 was used to assess heterogeneity and the random effect model (REM) was adopted as the pooling method. The pooled standard mean difference (SMD) with 95% confidence interval (CI) was used to estimate the association between serum zinc level and PE. Seventeen observational studies were included. Compared with healthy pregnancy controls, PE patients have lower serum zinc level in 14 studies about total PE (SMD (95% CI): −0.587 (−0.963, −0.212), Z = 3.06, p for Z = 0.002; I2 = 88.4%, p for I2 < 0.0001). In subgroup analysis, a lower serum zinc level in PE patients compared with healthy pregnancy controls was observed in studies conducted in Asia, studies with zinc level measured in serum, and studies involving fasting participants. The SMD did not differ significantly between studies with healthy pregnancy controls matched by individual age (yes or no), and by individual gestational age (yes or no), respectively. Results from this meta-analysis indicate that serum zinc level in PE patients is significantly lower than that in healthy pregnancy controls. A moderate amount of zinc supplementation during pregnancy is advocated to reduce the incidence of PE. |
topic |
zinc Zn preeclampsia meta-analysis |
url |
http://www.mdpi.com/2072-6643/7/9/5366 |
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