Early-Occurring Dendritic Spines Alterations in Mouse Models of Alzheimer’s Disease Inform on Primary Causes of Neurodegeneration

Early-Occurring Dendritic Spines Alterations in Mouse Models of Alzheimer’s Disease Inform on Primary Causes of Neurodegeneration

The consensus that synaptic failure is the earliest cause of cognitive deterioration in Alzheimer’s disease (AD) has initially led to investigate structural (dendritic spines) and physiological (LTP) synaptic dysfunctions in mouse models of AD with established cognitive alterations. The challenge is...

Full description

Bibliographic Details
Main Author: Martine Ammassari-Teule
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
Alzheimer’s disease
presymptomatic stage
full-length APP
Aβ oligomers (Aβo)
dendritic spines
synaptic proteins
Online Access:https://www.frontiersin.org/article/10.3389/fnsyn.2020.566615/full

Internet

https://www.frontiersin.org/article/10.3389/fnsyn.2020.566615/full

Similar Items