Metabolic disorders in acute infectious diarrhea in children

The purpose of the study: estimate the frequency of registration of different types of acid-base state disorders in children with acute infectious diarrhea; to determine the clinical features of acute intestinal infections that occur with metabolic acidosis (MA) and without it to choose the tactics...

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Main Authors: S. V. Khaliullina, V. A. Anokhin, Kh. S. Khaertynov, O. A. Nazarova
Format: Article
Language:Russian
Published: Ltd. “The National Academy of Pediatric Science and Innovation” 2017-11-01
Series:Rossijskij Vestnik Perinatologii i Pediatrii
Subjects:
Online Access:https://www.ped-perinatology.ru/jour/article/view/570
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spelling doaj-c0290a4883844b0da4ef84e2ce0d0cb82021-07-28T16:27:48ZrusLtd. “The National Academy of Pediatric Science and Innovation”Rossijskij Vestnik Perinatologii i Pediatrii1027-40652500-22282017-11-0162516116610.21508/1027-4065-2017-62-5-161-166511Metabolic disorders in acute infectious diarrhea in childrenS. V. Khaliullina0V. A. Anokhin1Kh. S. Khaertynov2O. A. Nazarova3Kazan State Medical University, Ministry of Health of the Russian FederationKazan State Medical University, Ministry of Health of the Russian FederationKazan State Medical University, Ministry of Health of the Russian FederationKazan State Medical University, Ministry of Health of the Russian FederationThe purpose of the study: estimate the frequency of registration of different types of acid-base state disorders in children with acute infectious diarrhea; to determine the clinical features of acute intestinal infections that occur with metabolic acidosis (MA) and without it to choose the tactics of effective correction.Мaterials and methods: retrospective cohort study was conducted of 246 patients hospitalized in a hospital with clinic of acute infectious diarrhea.Results of the study: laboratory-confirmed acidosis, were recorded in 40.7% (95% CI 34.6–46.8), 100/246 children, incl. With a pH below 7.25 in 9.3% (95% CI 5–7–12.9), 23/246. The condition of alkalosis revealed in 4.9% (95% CI 2.2–7.6) of 12/246 examined. Hyperchloremic acidosis had a place in 81% (95% CI 73.3–88.7), 81/100 patients, with a high anionic deficiency in 19% (95% CI 11.3–26.7), 19/100, P <0.001. Decompensated MA with pH <7.25 was recorded in 6.2% (95% CI 0.9–11.5), 5/81 examined with hyperchloremic acidosis and in 94.7% (95% CI 84.6–104, 8), 18/19 – with keto- and lactate-acidosis. Subcompensated MA was more often detected with rotavirus infection, RVI (50.6% (95% CI (39.4–61.8), 39/77), p <0.001. Metabolic disorders with RVI were more likely to correspond to acidosis with a high anion gap (52, 6% (95% CI 30.1–75.1) 10/19, p=0.02.) Bacterial diarrheas were more often observed in children without disturbances of the KHS (22.4% (95% CI 15.3–29, 5), 30/134), p=0.014. In assessing the characteristics of different types of MA we identified that the presence of tachypnea increases the probability of detecting acidosis with a high anion gap of 3.5 times (OR 3.5 CI 1.3–9.3).Conclusion: Our studies didn’t reveal pathognomonic clinical symptoms of various variants of metabolic acidosis.https://www.ped-perinatology.ru/jour/article/view/570childrenmetabolic disordersacidosisacute intestinal infections
collection DOAJ
language Russian
format Article
sources DOAJ
author S. V. Khaliullina
V. A. Anokhin
Kh. S. Khaertynov
O. A. Nazarova
spellingShingle S. V. Khaliullina
V. A. Anokhin
Kh. S. Khaertynov
O. A. Nazarova
Metabolic disorders in acute infectious diarrhea in children
Rossijskij Vestnik Perinatologii i Pediatrii
children
metabolic disorders
acidosis
acute intestinal infections
author_facet S. V. Khaliullina
V. A. Anokhin
Kh. S. Khaertynov
O. A. Nazarova
author_sort S. V. Khaliullina
title Metabolic disorders in acute infectious diarrhea in children
title_short Metabolic disorders in acute infectious diarrhea in children
title_full Metabolic disorders in acute infectious diarrhea in children
title_fullStr Metabolic disorders in acute infectious diarrhea in children
title_full_unstemmed Metabolic disorders in acute infectious diarrhea in children
title_sort metabolic disorders in acute infectious diarrhea in children
publisher Ltd. “The National Academy of Pediatric Science and Innovation”
series Rossijskij Vestnik Perinatologii i Pediatrii
issn 1027-4065
2500-2228
publishDate 2017-11-01
description The purpose of the study: estimate the frequency of registration of different types of acid-base state disorders in children with acute infectious diarrhea; to determine the clinical features of acute intestinal infections that occur with metabolic acidosis (MA) and without it to choose the tactics of effective correction.Мaterials and methods: retrospective cohort study was conducted of 246 patients hospitalized in a hospital with clinic of acute infectious diarrhea.Results of the study: laboratory-confirmed acidosis, were recorded in 40.7% (95% CI 34.6–46.8), 100/246 children, incl. With a pH below 7.25 in 9.3% (95% CI 5–7–12.9), 23/246. The condition of alkalosis revealed in 4.9% (95% CI 2.2–7.6) of 12/246 examined. Hyperchloremic acidosis had a place in 81% (95% CI 73.3–88.7), 81/100 patients, with a high anionic deficiency in 19% (95% CI 11.3–26.7), 19/100, P <0.001. Decompensated MA with pH <7.25 was recorded in 6.2% (95% CI 0.9–11.5), 5/81 examined with hyperchloremic acidosis and in 94.7% (95% CI 84.6–104, 8), 18/19 – with keto- and lactate-acidosis. Subcompensated MA was more often detected with rotavirus infection, RVI (50.6% (95% CI (39.4–61.8), 39/77), p <0.001. Metabolic disorders with RVI were more likely to correspond to acidosis with a high anion gap (52, 6% (95% CI 30.1–75.1) 10/19, p=0.02.) Bacterial diarrheas were more often observed in children without disturbances of the KHS (22.4% (95% CI 15.3–29, 5), 30/134), p=0.014. In assessing the characteristics of different types of MA we identified that the presence of tachypnea increases the probability of detecting acidosis with a high anion gap of 3.5 times (OR 3.5 CI 1.3–9.3).Conclusion: Our studies didn’t reveal pathognomonic clinical symptoms of various variants of metabolic acidosis.
topic children
metabolic disorders
acidosis
acute intestinal infections
url https://www.ped-perinatology.ru/jour/article/view/570
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AT vaanokhin metabolicdisordersinacuteinfectiousdiarrheainchildren
AT khskhaertynov metabolicdisordersinacuteinfectiousdiarrheainchildren
AT oanazarova metabolicdisordersinacuteinfectiousdiarrheainchildren
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