Metabolic disorders in acute infectious diarrhea in children
The purpose of the study: estimate the frequency of registration of different types of acid-base state disorders in children with acute infectious diarrhea; to determine the clinical features of acute intestinal infections that occur with metabolic acidosis (MA) and without it to choose the tactics...
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Ltd. “The National Academy of Pediatric Science and Innovation”
2017-11-01
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doaj-c0290a4883844b0da4ef84e2ce0d0cb82021-07-28T16:27:48ZrusLtd. “The National Academy of Pediatric Science and Innovation”Rossijskij Vestnik Perinatologii i Pediatrii1027-40652500-22282017-11-0162516116610.21508/1027-4065-2017-62-5-161-166511Metabolic disorders in acute infectious diarrhea in childrenS. V. Khaliullina0V. A. Anokhin1Kh. S. Khaertynov2O. A. Nazarova3Kazan State Medical University, Ministry of Health of the Russian FederationKazan State Medical University, Ministry of Health of the Russian FederationKazan State Medical University, Ministry of Health of the Russian FederationKazan State Medical University, Ministry of Health of the Russian FederationThe purpose of the study: estimate the frequency of registration of different types of acid-base state disorders in children with acute infectious diarrhea; to determine the clinical features of acute intestinal infections that occur with metabolic acidosis (MA) and without it to choose the tactics of effective correction.Мaterials and methods: retrospective cohort study was conducted of 246 patients hospitalized in a hospital with clinic of acute infectious diarrhea.Results of the study: laboratory-confirmed acidosis, were recorded in 40.7% (95% CI 34.6–46.8), 100/246 children, incl. With a pH below 7.25 in 9.3% (95% CI 5–7–12.9), 23/246. The condition of alkalosis revealed in 4.9% (95% CI 2.2–7.6) of 12/246 examined. Hyperchloremic acidosis had a place in 81% (95% CI 73.3–88.7), 81/100 patients, with a high anionic deficiency in 19% (95% CI 11.3–26.7), 19/100, P <0.001. Decompensated MA with pH <7.25 was recorded in 6.2% (95% CI 0.9–11.5), 5/81 examined with hyperchloremic acidosis and in 94.7% (95% CI 84.6–104, 8), 18/19 – with keto- and lactate-acidosis. Subcompensated MA was more often detected with rotavirus infection, RVI (50.6% (95% CI (39.4–61.8), 39/77), p <0.001. Metabolic disorders with RVI were more likely to correspond to acidosis with a high anion gap (52, 6% (95% CI 30.1–75.1) 10/19, p=0.02.) Bacterial diarrheas were more often observed in children without disturbances of the KHS (22.4% (95% CI 15.3–29, 5), 30/134), p=0.014. In assessing the characteristics of different types of MA we identified that the presence of tachypnea increases the probability of detecting acidosis with a high anion gap of 3.5 times (OR 3.5 CI 1.3–9.3).Conclusion: Our studies didn’t reveal pathognomonic clinical symptoms of various variants of metabolic acidosis.https://www.ped-perinatology.ru/jour/article/view/570childrenmetabolic disordersacidosisacute intestinal infections |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
S. V. Khaliullina V. A. Anokhin Kh. S. Khaertynov O. A. Nazarova |
spellingShingle |
S. V. Khaliullina V. A. Anokhin Kh. S. Khaertynov O. A. Nazarova Metabolic disorders in acute infectious diarrhea in children Rossijskij Vestnik Perinatologii i Pediatrii children metabolic disorders acidosis acute intestinal infections |
author_facet |
S. V. Khaliullina V. A. Anokhin Kh. S. Khaertynov O. A. Nazarova |
author_sort |
S. V. Khaliullina |
title |
Metabolic disorders in acute infectious diarrhea in children |
title_short |
Metabolic disorders in acute infectious diarrhea in children |
title_full |
Metabolic disorders in acute infectious diarrhea in children |
title_fullStr |
Metabolic disorders in acute infectious diarrhea in children |
title_full_unstemmed |
Metabolic disorders in acute infectious diarrhea in children |
title_sort |
metabolic disorders in acute infectious diarrhea in children |
publisher |
Ltd. “The National Academy of Pediatric Science and Innovation” |
series |
Rossijskij Vestnik Perinatologii i Pediatrii |
issn |
1027-4065 2500-2228 |
publishDate |
2017-11-01 |
description |
The purpose of the study: estimate the frequency of registration of different types of acid-base state disorders in children with acute infectious diarrhea; to determine the clinical features of acute intestinal infections that occur with metabolic acidosis (MA) and without it to choose the tactics of effective correction.Мaterials and methods: retrospective cohort study was conducted of 246 patients hospitalized in a hospital with clinic of acute infectious diarrhea.Results of the study: laboratory-confirmed acidosis, were recorded in 40.7% (95% CI 34.6–46.8), 100/246 children, incl. With a pH below 7.25 in 9.3% (95% CI 5–7–12.9), 23/246. The condition of alkalosis revealed in 4.9% (95% CI 2.2–7.6) of 12/246 examined. Hyperchloremic acidosis had a place in 81% (95% CI 73.3–88.7), 81/100 patients, with a high anionic deficiency in 19% (95% CI 11.3–26.7), 19/100, P <0.001. Decompensated MA with pH <7.25 was recorded in 6.2% (95% CI 0.9–11.5), 5/81 examined with hyperchloremic acidosis and in 94.7% (95% CI 84.6–104, 8), 18/19 – with keto- and lactate-acidosis. Subcompensated MA was more often detected with rotavirus infection, RVI (50.6% (95% CI (39.4–61.8), 39/77), p <0.001. Metabolic disorders with RVI were more likely to correspond to acidosis with a high anion gap (52, 6% (95% CI 30.1–75.1) 10/19, p=0.02.) Bacterial diarrheas were more often observed in children without disturbances of the KHS (22.4% (95% CI 15.3–29, 5), 30/134), p=0.014. In assessing the characteristics of different types of MA we identified that the presence of tachypnea increases the probability of detecting acidosis with a high anion gap of 3.5 times (OR 3.5 CI 1.3–9.3).Conclusion: Our studies didn’t reveal pathognomonic clinical symptoms of various variants of metabolic acidosis. |
topic |
children metabolic disorders acidosis acute intestinal infections |
url |
https://www.ped-perinatology.ru/jour/article/view/570 |
work_keys_str_mv |
AT svkhaliullina metabolicdisordersinacuteinfectiousdiarrheainchildren AT vaanokhin metabolicdisordersinacuteinfectiousdiarrheainchildren AT khskhaertynov metabolicdisordersinacuteinfectiousdiarrheainchildren AT oanazarova metabolicdisordersinacuteinfectiousdiarrheainchildren |
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