Primary cilia in corneal development and disease
As a transparent avascular tissue located at the front of the eyeball, the cornea is an important barrier to external damage. Both epithelial and endothelial cells of the cornea harbor primary cilia, which sense changes in the external environment and regulate intracellular signaling pathways. Accum...
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Science Press, PR China
2020-09-01
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Online Access: | http://www.zoores.ac.cn/EN/10.24272/j.issn.2095-8137.2020.109 |
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doaj-c0952234294e48a19ec10bdba40c78d52020-11-25T03:01:30ZengScience Press, PR ChinaZoological Research2095-81372020-09-0141549550210.24272/j.issn.2095-8137.2020.109ZR-2020-109Primary cilia in corneal development and diseaseTing Song0Jun Zhou1Institute of Biomedical Sciences, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan, Shandong 250014, ChinaInstitute of Biomedical Sciences, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan, Shandong 250014, ChinaAs a transparent avascular tissue located at the front of the eyeball, the cornea is an important barrier to external damage. Both epithelial and endothelial cells of the cornea harbor primary cilia, which sense changes in the external environment and regulate intracellular signaling pathways. Accumulating evidence suggests that the primary cilium regulates corneal development in several ways, including participation in corneal epithelial stratification and maintenance of corneal endothelial cell morphology. In addition, the primary cilium has been implicated in the pathogenesis of several corneal diseases. In this review, we discuss recent findings that demonstrate the critical role of the primary cilium in corneal development. We also discuss the link between ciliary dysfunction and corneal diseases, which suggests that the primary cilium could be targeted to treat these diseases.http://www.zoores.ac.cn/EN/10.24272/j.issn.2095-8137.2020.109corneadevelopmentdiseaseciliumepitheliumendotheliumtreatment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ting Song Jun Zhou |
spellingShingle |
Ting Song Jun Zhou Primary cilia in corneal development and disease Zoological Research cornea development disease cilium epithelium endothelium treatment |
author_facet |
Ting Song Jun Zhou |
author_sort |
Ting Song |
title |
Primary cilia in corneal development and disease |
title_short |
Primary cilia in corneal development and disease |
title_full |
Primary cilia in corneal development and disease |
title_fullStr |
Primary cilia in corneal development and disease |
title_full_unstemmed |
Primary cilia in corneal development and disease |
title_sort |
primary cilia in corneal development and disease |
publisher |
Science Press, PR China |
series |
Zoological Research |
issn |
2095-8137 |
publishDate |
2020-09-01 |
description |
As a transparent avascular tissue located at the front of the eyeball, the cornea is an important barrier to external damage. Both epithelial and endothelial cells of the cornea harbor primary cilia, which sense changes in the external environment and regulate intracellular signaling pathways. Accumulating evidence suggests that the primary cilium regulates corneal development in several ways, including participation in corneal epithelial stratification and maintenance of corneal endothelial cell morphology. In addition, the primary cilium has been implicated in the pathogenesis of several corneal diseases. In this review, we discuss recent findings that demonstrate the critical role of the primary cilium in corneal development. We also discuss the link between ciliary dysfunction and corneal diseases, which suggests that the primary cilium could be targeted to treat these diseases. |
topic |
cornea development disease cilium epithelium endothelium treatment |
url |
http://www.zoores.ac.cn/EN/10.24272/j.issn.2095-8137.2020.109 |
work_keys_str_mv |
AT tingsong primaryciliaincornealdevelopmentanddisease AT junzhou primaryciliaincornealdevelopmentanddisease |
_version_ |
1724693511787249664 |