Primary cilia in corneal development and disease

As a transparent avascular tissue located at the front of the eyeball, the cornea is an important barrier to external damage. Both epithelial and endothelial cells of the cornea harbor primary cilia, which sense changes in the external environment and regulate intracellular signaling pathways. Accum...

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Main Authors: Ting Song, Jun Zhou
Format: Article
Language:English
Published: Science Press, PR China 2020-09-01
Series:Zoological Research
Subjects:
Online Access:http://www.zoores.ac.cn/EN/10.24272/j.issn.2095-8137.2020.109
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spelling doaj-c0952234294e48a19ec10bdba40c78d52020-11-25T03:01:30ZengScience Press, PR ChinaZoological Research2095-81372020-09-0141549550210.24272/j.issn.2095-8137.2020.109ZR-2020-109Primary cilia in corneal development and diseaseTing Song0Jun Zhou1Institute of Biomedical Sciences, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan, Shandong 250014, ChinaInstitute of Biomedical Sciences, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan, Shandong 250014, ChinaAs a transparent avascular tissue located at the front of the eyeball, the cornea is an important barrier to external damage. Both epithelial and endothelial cells of the cornea harbor primary cilia, which sense changes in the external environment and regulate intracellular signaling pathways. Accumulating evidence suggests that the primary cilium regulates corneal development in several ways, including participation in corneal epithelial stratification and maintenance of corneal endothelial cell morphology. In addition, the primary cilium has been implicated in the pathogenesis of several corneal diseases. In this review, we discuss recent findings that demonstrate the critical role of the primary cilium in corneal development. We also discuss the link between ciliary dysfunction and corneal diseases, which suggests that the primary cilium could be targeted to treat these diseases.http://www.zoores.ac.cn/EN/10.24272/j.issn.2095-8137.2020.109corneadevelopmentdiseaseciliumepitheliumendotheliumtreatment
collection DOAJ
language English
format Article
sources DOAJ
author Ting Song
Jun Zhou
spellingShingle Ting Song
Jun Zhou
Primary cilia in corneal development and disease
Zoological Research
cornea
development
disease
cilium
epithelium
endothelium
treatment
author_facet Ting Song
Jun Zhou
author_sort Ting Song
title Primary cilia in corneal development and disease
title_short Primary cilia in corneal development and disease
title_full Primary cilia in corneal development and disease
title_fullStr Primary cilia in corneal development and disease
title_full_unstemmed Primary cilia in corneal development and disease
title_sort primary cilia in corneal development and disease
publisher Science Press, PR China
series Zoological Research
issn 2095-8137
publishDate 2020-09-01
description As a transparent avascular tissue located at the front of the eyeball, the cornea is an important barrier to external damage. Both epithelial and endothelial cells of the cornea harbor primary cilia, which sense changes in the external environment and regulate intracellular signaling pathways. Accumulating evidence suggests that the primary cilium regulates corneal development in several ways, including participation in corneal epithelial stratification and maintenance of corneal endothelial cell morphology. In addition, the primary cilium has been implicated in the pathogenesis of several corneal diseases. In this review, we discuss recent findings that demonstrate the critical role of the primary cilium in corneal development. We also discuss the link between ciliary dysfunction and corneal diseases, which suggests that the primary cilium could be targeted to treat these diseases.
topic cornea
development
disease
cilium
epithelium
endothelium
treatment
url http://www.zoores.ac.cn/EN/10.24272/j.issn.2095-8137.2020.109
work_keys_str_mv AT tingsong primaryciliaincornealdevelopmentanddisease
AT junzhou primaryciliaincornealdevelopmentanddisease
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