Deriving a dose and regimen for anti-glucosaminidase antibody passive-immunisation for patients with Staphylococcus aureus osteomyelitis

Deriving a dose and regimen for anti-glucosaminidase antibody passive-immunisation for patients with Staphylococcus aureus osteomyelitis

Staphylococcus aureus (S. aureus) osteomyelitis remains a major clinical problem. Anti-glucosaminidase (Gmd) antibodies (1C11) are efficacious in prophylactic and therapeutic murine models. Feasibility, safety and pharmacokinetics of 1C11 passive immunisation in sheep and endogenous anti-Gmd levels...

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Bibliographic Details
Main Authors: CC Lee, RD Southgate, C Jiao, E Gersz, JR Owen, SL Kates, CA Beck, C Xie, JL Daiss, V Post, TF Moriarty, S Zeiter, EM Schwarz, G Muthukrishnan
Format: Article
Language:English
Published: AO Research Institute Davos 2020-01-01
Series:European Cells & Materials
Subjects:
orthopaedic infections
immunoassay
staphylococcus aureus
osteomyelitis
peri-prosthetic joint infection
2-stage revision surgery
passive immunisation.
Online Access:https://www.ecmjournal.org/papers/vol039/pdf/v039a06.pdf

Internet

https://www.ecmjournal.org/papers/vol039/pdf/v039a06.pdf

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