A novel del(8)(q23.2q24.11) contributing to disease progression in a case of JAK2/TET2 double mutated chronic myelomonocytic leukemia

A novel del(8)(q23.2q24.11) contributing to disease progression in a case of JAK2/TET2 double mutated chronic myelomonocytic leukemia

We have identified a novel 7.7 Mb del(8)(q23.2q24.11) in a patient progressing to acute myeloid leukemia (AML) following a 12-year stable phase of chronic myelomonocytic leukemia (CMML). A surprisingly high JAK2+ allelic burden of 92% at the time of AML led us to delineate the molecular aberrations...

Full description

Bibliographic Details
Main Authors: Marie Toft-Petersen, Eigil Kjeldsen, Line Nederby, Kirsten Grønbæk, Peter Hokland, Anne Stidsholt Roug
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Leukemia Research Reports
Subjects:
del(8q)
CMML
TET2
JAK2
Transformation
Online Access:http://www.sciencedirect.com/science/article/pii/S221304891400020X

Internet

http://www.sciencedirect.com/science/article/pii/S221304891400020X

Similar Items