Yeast Assay Highlights the Intrinsic Genomic Instability of Human PML Intron 6 over Intron 3 and the Role of Replication Fork Proteins.

Yeast Assay Highlights the Intrinsic Genomic Instability of Human PML Intron 6 over Intron 3 and the Role of Replication Fork Proteins.

Human acute promyelocytic leukemia (APL) is characterized by a specific balanced translocation t(15;17)(q22;q21) involving the PML and RARA genes. In both de novo and therapy-related APL, the most frequent PML breakpoints are located within intron 6, and less frequently in intron 3; the precise mech...

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Bibliographic Details
Main Authors: Roland Chanet, Guy Kienda, Amélie Heneman-Masurel, Laurence Vernis, Bruno Cassinat, Philippe Guardiola, Pierre Fenaux, Christine Chomienne, Meng-Er Huang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4460018?pdf=render

Internet

http://europepmc.org/articles/PMC4460018?pdf=render

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