Atypical TNF-TNFR superfamily binding interface in the GITR-GITRL complex for T cell activation

Atypical TNF-TNFR superfamily binding interface in the GITR-GITRL complex for T cell activation

Summary: Glucocorticoid-induced tumor necrosis factor receptor family-related protein (GITR) is a critical regulatory molecule in modulation of T cell immune responses. Here we report the mouse GITR (mGITR) and mGITR ligand (mGITRL) complex structure and find that the binding interface of mGITR and...

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Bibliographic Details
Main Authors: Min Zhao, Lijun Fu, Yan Chai, Meng Sun, Yan Li, Shuo Wang, Jianxun Qi, Bin Zeng, Le Kang, George F. Gao, Shuguang Tan
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Cell Reports
Subjects:
TNFSF/TNFRSF
GITR-GITRL complex
crystal structure
atypical binding
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721011839

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http://www.sciencedirect.com/science/article/pii/S2211124721011839

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