Harnessing the heterogeneity of T cell differentiation fate to fine-tune generation of effector and memory T cells

Recent studies show that naïve T cells bearing identical T cell receptors (TCR) experience heterogeneous differentiation and clonal expansion processes. The factors controlling this outcome are not well characterized, and their contributions to immune cell dynamics are similarly poorly understood. I...

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Bibliographic Details
Main Authors: Chang eGong, Jennifer J Linderman, Denise eKirschner
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-02-01
Series:Frontiers in Immunology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00057/full