Myc-induced liver tumors in transgenic zebrafish can regress in tp53 null mutation.

Hepatocellular carcinoma (HCC) is currently one of the top lethal cancers with an increasing trend. Deregulation of MYC in HCC is frequently detected and always correlated with poor prognosis. As the zebrafish genome contains two differentially expressed zebrafish myc orthologs, myca and mycb, it re...

Full description

Bibliographic Details
Main Authors: Lili Sun, Anh Tuan Nguyen, Jan M Spitsbergen, Zhiyuan Gong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4303426?pdf=render