ICI 182,780-Regulated Gene Expression in DU145 Prostate Cancer Cells Is Mediated by Estrogen Receptor-β/NFκB Crosstalk

ICI 182,780-Regulated Gene Expression in DU145 Prostate Cancer Cells Is Mediated by Estrogen Receptor-β/NFκB Crosstalk

Estrogen receptor (ER)-β is the predominant ER subtype in prostate cancer (PCa). We previously demonstrated that ICI 182,780 (ICI), but not estrogens, exerted dose-dependent growth inhibition on DU145 PCa cells by an ER-β-mediated pathway. Transcriptional profiling detected a greater than three-fol...

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Bibliographic Details
Main Authors: Yuet-Kin Leung, Ying Gao, Kin-Mang Lau, Xiang Zhang, Shuk-Mei Ho
Format: Article
Language:English
Published: Elsevier 2006-04-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
cDNA microarray
Spi transcription factor
interleukins
embryonic growth/differentiation factor (GDF-1)
RYK tyrosine kinase
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558606800631

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http://www.sciencedirect.com/science/article/pii/S1476558606800631

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