Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin

Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin

Abstract Human KLK8/neuropsin, a kallikrein-related serine peptidase, is mostly expressed in skin and the hippocampus regions of the brain, where it regulates memory formation by synaptic remodeling. Substrate profiles of recombinant KLK8 were analyzed with positional scanning using fluorogenic tetr...

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Bibliographic Details
Main Authors: Mekdes Debela, Viktor Magdolen, Wolfgang Skala, Brigitta Elsässer, Eric L. Schneider, Charles S. Craik, Martin L. Biniossek, Oliver Schilling, Wolfram Bode, Hans Brandstetter, Peter Goettig
Format: Article
Language:English
Published: Nature Publishing Group 2018-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-29058-6

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https://doi.org/10.1038/s41598-018-29058-6

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