Activation of the Nuclear Factor E2-Related Factor 2 Pathway by Novel Natural Products Halomadurones A–D and a Synthetic Analogue

Activation of the Nuclear Factor E2-Related Factor 2 Pathway by Novel Natural Products Halomadurones A–D and a Synthetic Analogue

Two novel chlorinated pyrones, halomadurones A and B, and two novel brominated analogues, halomadurones C and D, were isolated from a marine Actinomadura sp. cultivated from the ascidian Ecteinascidia turbinata. Additionally, a non-halogenated analogue, 2-methyl-6-((E)-3-methyl-1,3-hexadiene)-γ-pyro...

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Bibliographic Details
Main Authors: Thomas P. Wyche, Miranda Standiford, Yanpeng Hou, Doug Braun, Delinda A. Johnson, Jeffrey A. Johnson, Tim S. Bugni
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:Marine Drugs
Subjects:
Ecteinascidia turbinata
halomadurones
Actinomadura
nuclear factor E2-related factor antioxidant response element
Online Access:http://www.mdpi.com/1660-3397/11/12/5089

Internet

http://www.mdpi.com/1660-3397/11/12/5089

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