PPARα-Selective Antagonist GW6471 Inhibits Cell Growth in Breast Cancer Stem Cells Inducing Energy Imbalance and Metabolic Stress

PPARα-Selective Antagonist GW6471 Inhibits Cell Growth in Breast Cancer Stem Cells Inducing Energy Imbalance and Metabolic Stress

Breast cancer is the most frequent cancer and the second leading cause of death among women. Triple-negative breast cancer is the most aggressive subtype of breast cancer and is characterized by the absence of hormone receptors and human epithelial growth factor receptor 2. Cancer stem cells (CSCs)...

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Bibliographic Details
Main Authors: Vanessa Castelli, Mariano Catanesi, Margherita Alfonsetti, Chiara Laezza, Francesca Lombardi, Benedetta Cinque, Maria Grazia Cifone, Rodolfo Ippoliti, Elisabetta Benedetti, Annamaria Cimini, Michele d’Angelo
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Biomedicines
Subjects:
mammospheres
CSCs
metabolism
spheroids
triple-negative breast cancer
MDA-MB-231
Online Access:https://www.mdpi.com/2227-9059/9/2/127

Internet

https://www.mdpi.com/2227-9059/9/2/127

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