Subcellular heterogeneity of ryanodine receptor properties in ventricular myocytes with low T-tubule density.

RATIONALE: In ventricular myocytes of large mammals, not all ryanodine receptor (RyR) clusters are associated with T-tubules (TTs); this fraction increases with cellular remodeling after myocardial infarction (MI). OBJECTIVE: To characterize RyR functional properties in relation to TT proximity, at...

Full description

Bibliographic Details
Main Authors: Liesbeth Biesmans, Niall Macquaide, Frank R Heinzel, Virginie Bito, Godfrey L Smith, Karin R Sipido
Format: Article
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access: