Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus

Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus

The chaperone Hsp90 is a potential target for the development of drugs against fungal pathogens. Here the authors determine the structure of the Hsp90 nucleotide-binding domain from Candida albicans, which they use to design an inhibitor and demonstrate its selectivity for the fungal enzyme, both bi...

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Bibliographic Details
Main Authors: Luke Whitesell, Nicole Robbins, David S. Huang, Catherine A. McLellan, Tanvi Shekhar-Guturja, Emmanuelle V. LeBlanc, Catherine S. Nation, Raymond Hui, Ashley Hutchinson, Cathy Collins, Sharanya Chatterjee, Richard Trilles, Jinglin L. Xie, Damian J. Krysan, Susan Lindquist, John A. Porco, Utpal Tatu, Lauren E. Brown, Juan Pizarro, Leah E. Cowen
Format: Article
Language:English
Published: Nature Publishing Group 2019-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-08248-w

Internet

https://doi.org/10.1038/s41467-018-08248-w

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