An inhibitory gate for state transition in cortex
Large scale transitions between active (up) and silent (down) states during quiet wakefulness or NREM sleep regulate fundamental cortical functions and are known to involve both excitatory and inhibitory cells. However, if and how inhibition regulates these activity transitions is unclear. Using flu...
Main Authors: | , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2017-05-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/26177 |
id |
doaj-c206d9bde67749daa7e688274ac6cec5 |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stefano Zucca Giulia D’Urso Valentina Pasquale Dania Vecchia Giuseppe Pica Serena Bovetti Claudio Moretti Stefano Varani Manuel Molano-Mazón Michela Chiappalone Stefano Panzeri Tommaso Fellin |
spellingShingle |
Stefano Zucca Giulia D’Urso Valentina Pasquale Dania Vecchia Giuseppe Pica Serena Bovetti Claudio Moretti Stefano Varani Manuel Molano-Mazón Michela Chiappalone Stefano Panzeri Tommaso Fellin An inhibitory gate for state transition in cortex eLife Neocortex parvalbumin positive interneuron somatostatin positive interneuron up and down states |
author_facet |
Stefano Zucca Giulia D’Urso Valentina Pasquale Dania Vecchia Giuseppe Pica Serena Bovetti Claudio Moretti Stefano Varani Manuel Molano-Mazón Michela Chiappalone Stefano Panzeri Tommaso Fellin |
author_sort |
Stefano Zucca |
title |
An inhibitory gate for state transition in cortex |
title_short |
An inhibitory gate for state transition in cortex |
title_full |
An inhibitory gate for state transition in cortex |
title_fullStr |
An inhibitory gate for state transition in cortex |
title_full_unstemmed |
An inhibitory gate for state transition in cortex |
title_sort |
inhibitory gate for state transition in cortex |
publisher |
eLife Sciences Publications Ltd |
series |
eLife |
issn |
2050-084X |
publishDate |
2017-05-01 |
description |
Large scale transitions between active (up) and silent (down) states during quiet wakefulness or NREM sleep regulate fundamental cortical functions and are known to involve both excitatory and inhibitory cells. However, if and how inhibition regulates these activity transitions is unclear. Using fluorescence-targeted electrophysiological recording and cell-specific optogenetic manipulation in both anesthetized and non-anesthetized mice, we found that two major classes of interneurons, the parvalbumin and the somatostatin positive cells, tightly control both up-to-down and down-to-up state transitions. Inhibitory regulation of state transition was observed under both natural and optogenetically-evoked conditions. Moreover, perturbative optogenetic experiments revealed that the inhibitory control of state transition was interneuron-type specific. Finally, local manipulation of small ensembles of interneurons affected cortical populations millimetres away from the modulated region. Together, these results demonstrate that inhibition potently gates transitions between cortical activity states, and reveal the cellular mechanisms by which local inhibitory microcircuits regulate state transitions at the mesoscale. |
topic |
Neocortex parvalbumin positive interneuron somatostatin positive interneuron up and down states |
url |
https://elifesciences.org/articles/26177 |
work_keys_str_mv |
AT stefanozucca aninhibitorygateforstatetransitionincortex AT giuliadurso aninhibitorygateforstatetransitionincortex AT valentinapasquale aninhibitorygateforstatetransitionincortex AT daniavecchia aninhibitorygateforstatetransitionincortex AT giuseppepica aninhibitorygateforstatetransitionincortex AT serenabovetti aninhibitorygateforstatetransitionincortex AT claudiomoretti aninhibitorygateforstatetransitionincortex AT stefanovarani aninhibitorygateforstatetransitionincortex AT manuelmolanomazon aninhibitorygateforstatetransitionincortex AT michelachiappalone aninhibitorygateforstatetransitionincortex AT stefanopanzeri aninhibitorygateforstatetransitionincortex AT tommasofellin aninhibitorygateforstatetransitionincortex AT stefanozucca inhibitorygateforstatetransitionincortex AT giuliadurso inhibitorygateforstatetransitionincortex AT valentinapasquale inhibitorygateforstatetransitionincortex AT daniavecchia inhibitorygateforstatetransitionincortex AT giuseppepica inhibitorygateforstatetransitionincortex AT serenabovetti inhibitorygateforstatetransitionincortex AT claudiomoretti inhibitorygateforstatetransitionincortex AT stefanovarani inhibitorygateforstatetransitionincortex AT manuelmolanomazon inhibitorygateforstatetransitionincortex AT michelachiappalone inhibitorygateforstatetransitionincortex AT stefanopanzeri inhibitorygateforstatetransitionincortex AT tommasofellin inhibitorygateforstatetransitionincortex |
_version_ |
1721461930699259904 |
spelling |
doaj-c206d9bde67749daa7e688274ac6cec52021-05-05T13:28:48ZengeLife Sciences Publications LtdeLife2050-084X2017-05-01610.7554/eLife.26177An inhibitory gate for state transition in cortexStefano Zucca0Giulia D’Urso1Valentina Pasquale2https://orcid.org/0000-0002-4499-9536Dania Vecchia3Giuseppe Pica4Serena Bovetti5Claudio Moretti6Stefano Varani7Manuel Molano-Mazón8Michela Chiappalone9Stefano Panzeri10https://orcid.org/0000-0003-1700-8909Tommaso Fellin11https://orcid.org/0000-0003-2718-7533Optical Approaches to Brain Function Laboratory, Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, Italy; Neural Coding Laboratory, Istituto Italiano di Tecnologia, Genova and Rovereto, ItalyOptical Approaches to Brain Function Laboratory, Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, Italy; Neural Coding Laboratory, Istituto Italiano di Tecnologia, Genova and Rovereto, ItalyDepartment of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, ItalyOptical Approaches to Brain Function Laboratory, Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, Italy; Neural Coding Laboratory, Istituto Italiano di Tecnologia, Genova and Rovereto, ItalyNeural Coding Laboratory, Istituto Italiano di Tecnologia, Genova and Rovereto, Italy; Neural Computation Laboratory, Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia, Rovereto, ItalyOptical Approaches to Brain Function Laboratory, Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, Italy; Neural Coding Laboratory, Istituto Italiano di Tecnologia, Genova and Rovereto, ItalyOptical Approaches to Brain Function Laboratory, Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, Italy; Neural Coding Laboratory, Istituto Italiano di Tecnologia, Genova and Rovereto, ItalyOptical Approaches to Brain Function Laboratory, Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, Italy; Neural Coding Laboratory, Istituto Italiano di Tecnologia, Genova and Rovereto, ItalyNeural Coding Laboratory, Istituto Italiano di Tecnologia, Genova and Rovereto, Italy; Neural Computation Laboratory, Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia, Rovereto, ItalyDepartment of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, ItalyOptical Approaches to Brain Function Laboratory, Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, Italy; Neural Coding Laboratory, Istituto Italiano di Tecnologia, Genova and Rovereto, Italy; Neural Computation Laboratory, Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia, Rovereto, ItalyOptical Approaches to Brain Function Laboratory, Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, Italy; Neural Coding Laboratory, Istituto Italiano di Tecnologia, Genova and Rovereto, ItalyLarge scale transitions between active (up) and silent (down) states during quiet wakefulness or NREM sleep regulate fundamental cortical functions and are known to involve both excitatory and inhibitory cells. However, if and how inhibition regulates these activity transitions is unclear. Using fluorescence-targeted electrophysiological recording and cell-specific optogenetic manipulation in both anesthetized and non-anesthetized mice, we found that two major classes of interneurons, the parvalbumin and the somatostatin positive cells, tightly control both up-to-down and down-to-up state transitions. Inhibitory regulation of state transition was observed under both natural and optogenetically-evoked conditions. Moreover, perturbative optogenetic experiments revealed that the inhibitory control of state transition was interneuron-type specific. Finally, local manipulation of small ensembles of interneurons affected cortical populations millimetres away from the modulated region. Together, these results demonstrate that inhibition potently gates transitions between cortical activity states, and reveal the cellular mechanisms by which local inhibitory microcircuits regulate state transitions at the mesoscale.https://elifesciences.org/articles/26177Neocortexparvalbumin positive interneuronsomatostatin positive interneuronup and down states |