Going Too Far Is the Same as Falling Short†: Kinesin-3 Family Members in Hereditary Spastic Paraplegia

Going Too Far Is the Same as Falling Short†: Kinesin-3 Family Members in Hereditary Spastic Paraplegia

Proper intracellular trafficking is essential for neuronal development and function, and when any aspect of this process is dysregulated, the resulting “transportopathy” causes neurological disorders. Hereditary spastic paraplegias (HSPs) are a family of such diseases attributed to over 80 spastic g...

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Bibliographic Details
Main Authors: Dominik R. Gabrych, Victor Z. Lau, Shinsuke Niwa, Michael A. Silverman
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
KIF1
axonal transport
hereditary spastic paraplegia (HSP)
neurodegenarative disease
vesicle trafficking
kinesin
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00419/full

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https://www.frontiersin.org/article/10.3389/fncel.2019.00419/full

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