Importance of heterogeneity in Porhyromonas gingivalis lipopolysaccharide lipid A in tissue specific inflammatory signalling

Importance of heterogeneity in Porhyromonas gingivalis lipopolysaccharide lipid A in tissue specific inflammatory signalling

Lipopolysaccharide (LPS) of Porphyromonas gingivalis exists in at least two known forms, O-LPS and A-LPS. A-LPS shows heterogeneity in which two isoforms designated LPS1,435/1,449 and LPS1,690 appear responsible for tissue-specific immune signalling pathways activation and increased virulence. The m...

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Bibliographic Details
Main Authors: Ingar Olsen, Sim K. Singhrao
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Journal of Oral Microbiology
Subjects:
P. gingivalis
lipid A
heterogeneity
penta-acylated form
tetra-acylated form
innate immunity subversion
Online Access:http://dx.doi.org/10.1080/20002297.2018.1440128

Internet

http://dx.doi.org/10.1080/20002297.2018.1440128

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