STAT2 Signaling Regulates Macrophage Phenotype During Influenza and Bacterial Super-Infection

STAT2 Signaling Regulates Macrophage Phenotype During Influenza and Bacterial Super-Infection

Influenza is a common respiratory virus that infects between 5 and 20% of the US population and results in 30,000 deaths annually. A primary cause of influenza-associated death is secondary bacterial pneumonia. We have previously shown that influenza induces type I interferon (IFN)-mediated inhibiti...

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Bibliographic Details
Main Authors: Radha Gopal, Benjamin Lee, Kevin J. McHugh, Helen E. Rich, Krishnaveni Ramanan, Sivanarayana Mandalapu, Michelle E. Clay, Philip J. Seger, Richard I. Enelow, Michelle L. Manni, Keven M. Robinson, Javier Rangel-Moreno, John F. Alcorn
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
influenza
Staphylococcus aureus
super-infection
STAT2
macrophages
lung
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02151/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02151/full

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