Molecular characterization and mapping of glucose-6-phosphate dehydrogenase (G6PD) mutations in the Greater Mekong Subregion

Molecular characterization and mapping of glucose-6-phosphate dehydrogenase (G6PD) mutations in the Greater Mekong Subregion

Abstract Background Plasmodium vivax malaria elimination can only be achieved by the deployment of 8-aminoquinolines (primaquine and tafenoquine) in combination with ACT to kill both blood and liver-stage parasites. However, primaquine and the other 8-aminoquinolines cause dose-dependent haemolysis...

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Main Authors: Germana Bancone, Didier Menard, Nimol Khim, Saorin Kim, Lydie Canier, Chea Nguong, Koukeo Phommasone, Mayfong Mayxay, Sabine Dittrich, Malavanh Vongsouvath, Nadine Fievet, Jean-Yves Le Hesran, Valerie Briand, Sommay Keomany, Paul N. Newton, Gornpan Gorsawun, Kaelan Tardy, Cindy S. Chu, Orpreeya Rattanapalroj, Le Thanh Dong, Huynh Hong Quang, Nguyen Tam-Uyen, Nguyen Thuy-Nhien, Tran Tinh Hien, Michael Kalnoky, Francois Nosten
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Malaria Journal
Online Access:http://link.springer.com/article/10.1186/s12936-019-2652-y

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http://link.springer.com/article/10.1186/s12936-019-2652-y

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