Suppression of Th1 and Th17 Responses and Induction of Treg Responses by IL-18-Expressing Plasmid Gene Combined with IL-4 on Collagen-Induced Arthritis
Objectives. IL-18 is a proinflammatory cytokine with multiple immunoregulatory properties. We studied the effect of IL-18 gene therapy on the development of murine collagen-induced arthritis (CIA). Methods. Plasmid pCAGGS-IL-18 along or in combination with IL-10 or IL-4 was administered to CIA mice....
|Main Authors:||, , ,|
|Series:||BioMed Research International|