Suppression of Th1 and Th17 Responses and Induction of Treg Responses by IL-18-Expressing Plasmid Gene Combined with IL-4 on Collagen-Induced Arthritis

Objectives. IL-18 is a proinflammatory cytokine with multiple immunoregulatory properties. We studied the effect of IL-18 gene therapy on the development of murine collagen-induced arthritis (CIA). Methods. Plasmid pCAGGS-IL-18 along or in combination with IL-10 or IL-4 was administered to CIA mice....

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Bibliographic Details
Main Authors: Qiaomei Dai, Yang Li, Haiyue Yu, Xiaoyan Wang
Format: Article
Published: Hindawi Limited 2018-01-01
Series:BioMed Research International
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