Suppression and activation of the malignant phenotype by extracellular matrix in xenograft models of bladder cancer: a model for tumor cell "dormancy".

Suppression and activation of the malignant phenotype by extracellular matrix in xenograft models of bladder cancer: a model for tumor cell "dormancy".

A major problem in cancer research is the lack of a tractable model for delayed metastasis. Herein we show that cancer cells suppressed by SISgel, a gel-forming normal ECM material derived from Small Intestine Submucosa (SIS), in flank xenografts show properties of suppression and re-activation that...

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Bibliographic Details
Main Authors: Robert E Hurst, Paul J Hauser, Kimberly D Kyker, Jonathan E Heinlen, Jason P Hodde, Michael C Hiles, Stanley D Kosanke, Mikhail Dozmorov, Michael A Ihnat
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3663841?pdf=render

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http://europepmc.org/articles/PMC3663841?pdf=render

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