Serum Osteoprotegerin and Carotid Intima-Media Thickness Are Related to High Arterial Stiffness in Heart Failure with Reduced Ejection Fraction
Arterial stiffness (AS) is a complex vascular phenomenon with consequences for central hemodynamics and left-ventricular performance. Circulating biomarkers have been associated with AS; however, their value in heart failure is poorly characterized. Our aim was to evaluate the clinical and biomarker...
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doaj-c46fada3cebe40d8ba372fa08eb165d82021-04-24T23:00:10ZengMDPI AGDiagnostics2075-44182021-04-011176476410.3390/diagnostics11050764Serum Osteoprotegerin and Carotid Intima-Media Thickness Are Related to High Arterial Stiffness in Heart Failure with Reduced Ejection FractionLajos Fehérvári0Attila Frigy1Lóránd Kocsis2István Adorján Szabó3Timea Magdolna Szabo4Melinda Urkon5Zita Jakó6Előd Ernő Nagy7Department of Cardiology, Clinical County Hospital Mures, 540103 Targu Mures, RomaniaDepartment of Cardiology, Clinical County Hospital Mures, 540103 Targu Mures, RomaniaDepartment of Cardiology, Clinical County Hospital Mures, 540103 Targu Mures, RomaniaDepartment of Cardiology, Clinical County Hospital Mures, 540103 Targu Mures, RomaniaDepartment of Cardiology, Clinical County Hospital Mures, 540103 Targu Mures, RomaniaDepartment of Biochemistry and Environmental Chemistry, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, RomaniaLaboratory of Medical Analysis, Emergency Clinical County Hospital Targu Mures, 540136 Targu Mures, RomaniaDepartment of Biochemistry and Environmental Chemistry, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, RomaniaArterial stiffness (AS) is a complex vascular phenomenon with consequences for central hemodynamics and left-ventricular performance. Circulating biomarkers have been associated with AS; however, their value in heart failure is poorly characterized. Our aim was to evaluate the clinical and biomarker correlates of AS in the setting of heart failure with reduced ejection fraction (HFrEF). In 78 hospitalized, hemodynamically stable patients (20 women, 58 men, mean age 65.8 ± 1.41 years) with HFrEF, AS was measured using aortic pulse wave velocity (PWV). Serum OPG, RANKL, sclerostin, and DKK-1 were determined, and the relationships between the clinical variables, vascular-calcification-related biomarkers, and PWV were evaluated by correlation analysis and linear and logistic regression models. OPG and the OPG/RANKL ratio were significantly higher in the group of patients (<i>n</i> = 37, 47.4%) with increased PWV (>10 m/s). PWV was positively correlated with age, left-ventricular ejection fraction, and carotid intima-media thickness (cIMT), and negatively correlated with the glomerular filtration rate. OPG and cIMT were significantly associated with PWV in the logistic regression models when adjusted for hypertension, EF, and the presence of atherosclerotic manifestations. Elevated serum OPG, together with cIMT, were significantly related to increased AS in the setting of HFrEF.https://www.mdpi.com/2075-4418/11/5/764osteoprotegerincalcification biomarkersarterial stiffnesspulse wave velocityheart failure |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lajos Fehérvári Attila Frigy Lóránd Kocsis István Adorján Szabó Timea Magdolna Szabo Melinda Urkon Zita Jakó Előd Ernő Nagy |
spellingShingle |
Lajos Fehérvári Attila Frigy Lóránd Kocsis István Adorján Szabó Timea Magdolna Szabo Melinda Urkon Zita Jakó Előd Ernő Nagy Serum Osteoprotegerin and Carotid Intima-Media Thickness Are Related to High Arterial Stiffness in Heart Failure with Reduced Ejection Fraction Diagnostics osteoprotegerin calcification biomarkers arterial stiffness pulse wave velocity heart failure |
author_facet |
Lajos Fehérvári Attila Frigy Lóránd Kocsis István Adorján Szabó Timea Magdolna Szabo Melinda Urkon Zita Jakó Előd Ernő Nagy |
author_sort |
Lajos Fehérvári |
title |
Serum Osteoprotegerin and Carotid Intima-Media Thickness Are Related to High Arterial Stiffness in Heart Failure with Reduced Ejection Fraction |
title_short |
Serum Osteoprotegerin and Carotid Intima-Media Thickness Are Related to High Arterial Stiffness in Heart Failure with Reduced Ejection Fraction |
title_full |
Serum Osteoprotegerin and Carotid Intima-Media Thickness Are Related to High Arterial Stiffness in Heart Failure with Reduced Ejection Fraction |
title_fullStr |
Serum Osteoprotegerin and Carotid Intima-Media Thickness Are Related to High Arterial Stiffness in Heart Failure with Reduced Ejection Fraction |
title_full_unstemmed |
Serum Osteoprotegerin and Carotid Intima-Media Thickness Are Related to High Arterial Stiffness in Heart Failure with Reduced Ejection Fraction |
title_sort |
serum osteoprotegerin and carotid intima-media thickness are related to high arterial stiffness in heart failure with reduced ejection fraction |
publisher |
MDPI AG |
series |
Diagnostics |
issn |
2075-4418 |
publishDate |
2021-04-01 |
description |
Arterial stiffness (AS) is a complex vascular phenomenon with consequences for central hemodynamics and left-ventricular performance. Circulating biomarkers have been associated with AS; however, their value in heart failure is poorly characterized. Our aim was to evaluate the clinical and biomarker correlates of AS in the setting of heart failure with reduced ejection fraction (HFrEF). In 78 hospitalized, hemodynamically stable patients (20 women, 58 men, mean age 65.8 ± 1.41 years) with HFrEF, AS was measured using aortic pulse wave velocity (PWV). Serum OPG, RANKL, sclerostin, and DKK-1 were determined, and the relationships between the clinical variables, vascular-calcification-related biomarkers, and PWV were evaluated by correlation analysis and linear and logistic regression models. OPG and the OPG/RANKL ratio were significantly higher in the group of patients (<i>n</i> = 37, 47.4%) with increased PWV (>10 m/s). PWV was positively correlated with age, left-ventricular ejection fraction, and carotid intima-media thickness (cIMT), and negatively correlated with the glomerular filtration rate. OPG and cIMT were significantly associated with PWV in the logistic regression models when adjusted for hypertension, EF, and the presence of atherosclerotic manifestations. Elevated serum OPG, together with cIMT, were significantly related to increased AS in the setting of HFrEF. |
topic |
osteoprotegerin calcification biomarkers arterial stiffness pulse wave velocity heart failure |
url |
https://www.mdpi.com/2075-4418/11/5/764 |
work_keys_str_mv |
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