Regeneration of Cochlear Synapses by Systemic Administration of a Bisphosphonate

Regeneration of Cochlear Synapses by Systemic Administration of a Bisphosphonate

Sensorineural hearing loss (SNHL) caused by noise exposure and attendant loss of glutamatergic synapses between cochlear spiral ganglion neurons (SGNs) and hair cells is the most common sensory deficit worldwide. We show here that systemic administration of a bisphosphonate to mice 24 h after synapt...

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Bibliographic Details
Main Authors: Richard Seist, Mingjie Tong, Lukas D. Landegger, Sasa Vasilijic, Hiroshi Hyakusoku, Sachiyo Katsumi, Charles E. McKenna, Albert S. B. Edge, Konstantina M. Stankovic
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
auditory nerve
cochlear synaptopathy
noise-induced hearing loss
hidden hearing loss
bisphosphonate
synapse regeneration
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.00087/full
Description
Summary:Sensorineural hearing loss (SNHL) caused by noise exposure and attendant loss of glutamatergic synapses between cochlear spiral ganglion neurons (SGNs) and hair cells is the most common sensory deficit worldwide. We show here that systemic administration of a bisphosphonate to mice 24 h after synaptopathic noise exposure regenerated synapses between inner hair cells and SGNs and restored cochlear function. We further demonstrate that this effect is mediated by inhibition of the mevalonate pathway. These results are highly significant because they suggest that bisphosphonates could reverse cochlear synaptopathy for the treatment of SNHL.
ISSN:1662-5099

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